Iqsec2 - IQ motif and Sec7 domain 2 Gene

Also Known as Brag1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 245666

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin Cytoskeleton organization; modulation of chemical synaptic transmission; and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Located in presynaptic active zone cytoplasmic component. Is active in glutamatergic synapse; photoreceptor ribbon synapse; and postsynaptic density. Is expressed in brain. Used to study non-syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2). [provided by Alliance of Genome Resources, Apr 2022]

Iqsec2 Products (8)

mRNA Protein Name
NM_001005475.3 NP_001005475.1 IQ motif and SEC7 domain-containing protein 2 isoform 2
NM_001114664.3 NP_001108136.1 IQ motif and SEC7 domain-containing protein 2 isoform 1
NM_001405945.1 NP_001392874.1 IQ motif and SEC7 domain-containing protein 2 isoform 3
NM_001405946.1 NP_001392875.1 IQ motif and SEC7 domain-containing protein 2 isoform 4
NM_001405947.1 NP_001392876.1 IQ motif and SEC7 domain-containing protein 2 isoform 5
NM_001405948.1 NP_001392877.1 IQ motif and SEC7 domain-containing protein 2 isoform 6
NM_001405949.1 NP_001392878.1 IQ motif and SEC7 domain-containing protein 2 isoform 7
NM_001405950.1 NP_001392879.1 IQ motif and SEC7 domain-containing protein 2 isoform 8

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18164504 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
18164504 MGI
is active in photoreceptor ribbon synapse IDA
IDA: Inferred from direct assay
19811534 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
18164504 MGI
is active in postsynaptic density membrane IEP
IEP: Inferred from expression pattern
18164504 MGI
is active in postsynaptic density membrane IMP
IMP: Inferred from mutant phenotype
18164504 MGI
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
18164504 MGI
is active in postsynaptic density, intracellular component IEP
IEP: Inferred from expression pattern
18164504 MGI
is active in presynaptic active zone cytoplasmic component IDA
IDA: Inferred from direct assay
19811534 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

IQ motif and SEC7 domain-containing protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06889 IQSEC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Iqsec2 NCBI NCBI:23096