VGLL2 - vestigial like family member 2 Gene

Also Known as VGL2; VITO1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 245806

About VGLL2

Cytogenetic location: 6q22.1 Genomic coordinates (GRCh38): 6:117,265,558-117,273,630 (from NCBI)

This gene has 2 transcripts (splice variants), 191 orthologues and 2 paralogues. Biased expression in heart (RPKM 1.5), prostate (RPKM 0.6) and 4 other tissues.

Summary

This gene encodes a protein with a transcriptional enhancer factor 1 (TEF-1) interaction domain. The encoded protein may act as a co-factor of TEF-1 regulated gene expression during skeletal muscle development. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

VGLL2 Products (2)

mRNA Protein Name
NM_153453.1 NP_703154.1 transcription cofactor vestigial-like protein 2 isoform 2
NM_182645.3 NP_872586.1 transcription cofactor vestigial-like protein 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VGLL2 Protein Structure

Vg_Tdu

Vg_Tdu: Vestigial/Tondu family (79 - 111)

  • 0
  • 100
  • 200
  • 300
  • 317 a.a.
Protein Preferred Names Protein Names

transcription cofactor vestigial-like protein 2

  • Vestigial and Tondu related protein 1

Related Diseases

Diseases Alias
Spindle Cell Rhabdomyosarcoma
Pleomorphic Rhabdomyosarcoma

  • Adult Pleomorphic Rhabdomyosarcoma

  • Anaplastic Rhabdomyosarcoma

  • Pleomorphic Rhabdomyosarcoma, Adult Type
Cellular Congenital Mesoblastic Nephroma
Progressive Relapsing Multiple Sclerosis

  • Prms

  • Progressive-Relapsing Ms

  • Multiple Sclerosis, Progressive Relapsing
Congenital Fibrosarcoma

  • Infantile Fibrosarcoma
Childhood Fibrosarcoma

  • Pediatric Fibrosarcoma
Lipofibromatosis-Like Neural Tumor
Smarca4-Deficient Sarcoma Of Thorax

  • Smarca4-Dts

  • Smarca4-Deficient Thoracic Sarcoma
Myofibroma

  • Lipoleiomyoma

  • Uterine Fibroids

  • Solitary Myofibromatosis

  • Myolipoma
Kidney Sarcoma

  • Renal Sarcoma

  • Sarcoma Of Kidney
Malignant Pineal Area Germ Cell Neoplasm

  • Pineal Germ Cell Tumor

  • Malignant Pineal Parenchymal Germ Cell Tumor

  • Pineal Region Germ Cell Tumor

  • Pineal Cell Tumor

  • Pineal Cell Tumour

  • Pineal Region Germinoma

  • Malignant Pineal Region Germ Cell Tumor

  • Pineal Germinoma
Kidney Clear Cell Sarcoma

  • Clear Cell Sarcoma Of Kidney

  • Childhood Kidney Clear Cell Sarcoma

  • Renal Clear Cell Sarcoma

  • Ccsk

  • Clear Cell Sarcoma Of The Kidney
Rhabdomyosarcoma
Embryonal Rhabdomyosarcoma

  • Rhabdomyosarcoma, Embryonal

  • Rhabdomyosarcoma Embryonal

  • Botryoid Rhabdomyosarcoma

  • Erms

  • Spindle Cell Rhabdomyosarcomas
Spindle Cell Sarcoma

  • Sarcoma

  • Sarcoma Spindle Cell

  • Sarcoma, Spindle Cell

  • Sarcoma - Category
Skeletal Muscle Cancer

  • Malignant Tumor Of Skeletal Muscle

  • Skeletal Muscle Neoplasm
Rhabdomyosarcoma 2

  • Alveolar Rhabdomyosarcoma

  • Rhabdomyosarcoma, Alveolar

  • Rhabdomyosarcoma Alveolar

  • RMS2

  • Rmsa

  • Rhabdomyosarcoma 2, Alveolar

  • Alveolar Childhood Rhabdomyosarcoma

  • Arms

  • Rhabdomyosarcoma, Type 2
Muscle Cancer

  • Myosarcoma

  • Malignant Neoplasm Of Muscle

  • Malignant Tumor Of Muscle

  • Malignant Tumor Of The Muscle

  • Muscle Neoplasms

  • Myomatous Neoplasm
Craniometaphyseal Dysplasia, Autosomal Dominant

  • Craniometaphyseal Dysplasia

  • CMDD

  • Cmdj

  • Cmd

  • Autosomal Dominant Craniometaphyseal Dysplasia

  • Craniometaphyseal Dysplasia, Jackson Type

  • Craniometaphyseal Dysplasia Jackson Type

  • Autosomal Recessive Craniometaphyseal Dysplasia

  • Cmdr

  • Dysplasia, Craniometaphyseal, Autosomal Dominant

  • Craniometaphyseal Dysplasia, Autosomal Recessive Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15645 VGLL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus VGLL2 VGNC VGNC:102546
Mus musculus VGLL2 MGD MGI:2447460
Macaca mulatta VGLL2 VGNC VGNC:79237
Canis familiaris VGLL2 VGNC VGNC:48258
Rattus norvegicus VGLL2 RGD RGD:1311903
Bos taurus VGLL2 VGNC VGNC:36791