Wasf3 - WASP family, member 3 Gene

Also Known as Scar3; Wave3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 245880

Summary

Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Involved in modification of postsynaptic actin Cytoskeleton. Acts upstream of or within lamellipodium assembly; oligodendrocyte development; and positive regulation of myelination. Located in lamellipodium and postsynapse. Is active in glutamatergic synapse. Is expressed in adrenal gland; cap mesenchyme; nervous system; and neural retina. Orthologous to human WASF3 (WASP family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Wasf3 Products (1)

mRNA Protein Name
NM_145155.3 NP_660137.1 actin-binding protein WASF3

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
16723544 MGI
involved in modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
16190876 MGI
involved in modification of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
16190876 MGI
acts upstream of or within oligodendrocyte development IMP
IMP: Inferred from mutant phenotype
16723544 MGI
acts upstream of or within positive regulation of myelination IDA
IDA: Inferred from direct assay
16723544 MGI
acts upstream of or within positive regulation of myelination IMP
IMP: Inferred from mutant phenotype
16723544 MGI
Cellular Component GO Annotation Evidence References Source
located in glial cell projection IDA
IDA: Inferred from direct assay
16723544 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16190876 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
16190876 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
16723544 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
16190876 MGI
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
16190876 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin-binding protein WASF3

wiskott-Aldrich syndrome protein family member 3

  • WAS protein family, member 3

  • WASP family protein member 3

  • protein WAVE-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15744 WASF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wasf3 NCBI NCBI:10810