Wasf3 - WASP family, member 3 Gene

Mus musculus

Also known as Scar3; Wave3

Gene ID: 245880 | Gene type: protein coding

About Wasf3

Summary

Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Involved in modification of postsynaptic actin Cytoskeleton. Acts upstream of or within lamellipodium assembly; oligodendrocyte development; and positive regulation of myelination. Located in lamellipodium and postsynapse. Is active in glutamatergic synapse. Is expressed in adrenal gland; cap mesenchyme; nervous system; and neural retina. Orthologous to human WASF3 (WASP family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Wasf3 Products(1)

mRNA	Protein	Name
NM_145155.3	NP_660137.1	actin-binding protein WASF3

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	16723544	MGI
involved in modification of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	16190876	MGI
involved in modification of postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	16190876	MGI
acts upstream of or within oligodendrocyte development	IMP IMP: Inferred from mutant phenotype	16723544	MGI
acts upstream of or within positive regulation of myelination	IDA IDA: Inferred from direct assay	16723544	MGI
acts upstream of or within positive regulation of myelination	IMP IMP: Inferred from mutant phenotype	16723544	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in glial cell projection	IDA IDA: Inferred from direct assay	16723544	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16190876	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	16190876	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	16723544	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	16190876	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	16190876	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

actin-binding protein WASF3

wiskott-Aldrich syndrome protein family member 3

WAS protein family, member 3	WASP family protein member 3
protein WAVE-3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15744	WASF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wasf3	NCBI	NCBI:10810

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