FGD4 - Fgd4 FYVE, RhoGEF and PH domain containing 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 246174

Summary

Enables actin filament binding activity. Involved in positive regulation of JNK cascade and regulation of cell shape. Acts upstream of or within positive regulation of JUN kinase activity. Predicted to be located in filopodium and lamellipodium. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4H. Orthologous to human FGD4 (FYVE, RhoGEF and PH domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]

FGD4 Products (1)

mRNA	Protein	Name
NM_139263.2	NP_640356.1	FYVE, RhoGEF and PH domain-containing protein 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables actin binding	IDA IDA: Inferred from direct assay	9668039	RGD
enables actin filament binding	IMP IMP: Inferred from mutant phenotype	9668039	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	9668039	RGD
acts upstream of or within positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	9668039	RGD
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	9668039	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
FYVE, RhoGEF and PH domain-containing protein 4	FGD1-related F-actin-binding protein actin filament-binding protein frabin

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04883	FGD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	FGD4	NCBI	NCBI:121512