Pygm - glycogen phosphorylase, muscle associated Gene

Rattus norvegicus

Also known as Muscpho

Gene ID: 24701 | Gene type: protein coding

About Pygm

Summary

Enables anion binding activity; carbohydrate binding activity; and glycogen Phosphorylase activity. Involved in several processes, including glycogen catabolic process; response to cAMP; and response to hypoxia. Located in sarcoplasmic reticulum. Used to study cholestasis. Human ortholog(s) of this gene implicated in glycogen storage disease V. Orthologous to human PYGM (glycogen Phosphorylase, muscle associated). [provided by Alliance of Genome Resources, Apr 2022]

Pygm Products(1)

mRNA	Protein	Name
NM_012638.1	NP_036770.1	glycogen phosphorylase, muscle form

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables AMP binding	IDA IDA: Inferred from direct assay	14674711	RGD
enables carbohydrate binding	IDA IDA: Inferred from direct assay	6449198	RGD
enables glycogen phosphorylase activity	IDA IDA: Inferred from direct assay	6244274	RGD
enables organic cyclic compound binding	IDA IDA: Inferred from direct assay	17095214	RGD
enables pyridoxal phosphate binding	IDA IDA: Inferred from direct assay	11692172	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in glycogen catabolic process	IDA IDA: Inferred from direct assay	6449198	RGD
involved in glycogen metabolic process	IDA IDA: Inferred from direct assay	6244274	RGD
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	8810099	RGD
involved in response to cAMP	IDA IDA: Inferred from direct assay	14579114	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	14674711	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	11692172	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glycogen phosphorylase, muscle form

Phosphorylase glycogen	Phosphorylase, glycogen
muscle (McArdle syndrome)	muscle (McArdle syndrome)
muscle glycogen phosphorylase	myophosphorylase
phosphorylase, glycogen, muscle

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11490	PYGM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pygm	NCBI	NCBI:5837

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