Hnf1a - HNF1 homeobox A Gene

Also Known as HNF1; Lfb1; Tcf1; LF-B1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24817

Summary

Enables DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription, DNA-templated. Located in chromatin and nucleus. Part of protein-containing complex. Used to study hepatocellular adenoma and hepatocellular carcinoma. Biomarker of extrahepatic cholestasis and kidney disease. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); liver disease (multiple); and renal cell carcinoma. Orthologous to human HNF1A (HNF1 homeobox A). [provided by Alliance of Genome Resources, Apr 2022]

Hnf1a Products (1)

mRNA Protein Name
NM_012669.1 NP_036801.1 hepatocyte nuclear factor 1-alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
1763325 RGD
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
20735474 RGD
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
1763325 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
14561216 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12753154 RGD
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
15598887 RGD
enables transcription coregulator binding IPI
IPI: Inferred from physical interaction
15598887 RGD
Biological Process GO Annotation Evidence References Source
involved in activation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
20841353 RGD
involved in apoptotic nuclear changes IMP
IMP: Inferred from mutant phenotype
20841353 RGD
involved in cellular response to L-leucine IMP
IMP: Inferred from mutant phenotype
21874357 RGD
involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
20841353 RGD
involved in cellular response to rapamycin IMP
IMP: Inferred from mutant phenotype
21874357 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20841353 RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
21874357 RGD
involved in negative regulation of miRNA processing IMP
IMP: Inferred from mutant phenotype
23674172 RGD
involved in negative regulation of peptidyl-threonine phosphorylation IMP
IMP: Inferred from mutant phenotype
20841353 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7937157 RGD
involved in positive regulation of ATP biosynthetic process IMP
IMP: Inferred from mutant phenotype
20841353 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20841353 RGD
involved in positive regulation of insulin secretion IEP
IEP: Inferred from expression pattern
10944108 RGD
involved in positive regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
10944108 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
21874357 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
21874357 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7937157 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15598887 RGD
involved in regulation of NADP metabolic process IMP
IMP: Inferred from mutant phenotype
20841353 RGD
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14561216 RGD
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
15598887 RGD
located in nucleus IDA
IDA: Inferred from direct assay
1763325 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15598887 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatocyte nuclear factor 1-alpha

  • HNF-1-alpha

  • HNF-1A

  • LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1

  • TCF-1

  • Transcription factor 1, hepatic

  • albumin proximal factor

  • hepatic nuclear factor 1

  • hepatic nuclear factor-1-alpha

  • liver-specific transcription factor L

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06255 HNF1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174669 Human HNF1A mRNA / Unkown
HY-RS19690 Hnf1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26185 Hnf1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hnf1a NCBI NCBI:6927