Gabrb3 - gamma-aminobutyric acid type A receptor subunit beta 3 Gene

Rattus norvegicus

Gene ID: 24922 | Gene type: protein coding

About Gabrb3

Summary

Enables AP-2 adaptor complex binding activity; GABA-A receptor activity; and Chloride Channel activity. Involved in GABAergic synaptic transmission. Located in inhibitory synapse; plasma membrane; and terminal bouton. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in childhood absence epilepsy and developmental and epileptic encephalopathy 43. Orthologous to human GABRB3 (gamma-aminobutyric acid type A receptor subunit beta3). [provided by Alliance of Genome Resources, Apr 2022]

Gabrb3 Products(1)

mRNA	Protein	Name
NM_017065.2	NP_058761.2	gamma-aminobutyric acid receptor subunit beta-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables AP-2 adaptor complex binding	IPI IPI: Inferred from physical interaction	16192353	RGD
enables GABA-A receptor activity	IDA IDA: Inferred from direct assay	2548852	RGD
enables GABA-gated chloride ion channel activity	IDA IDA: Inferred from direct assay	10462548	RGD
enables chloride channel activity	IDA IDA: Inferred from direct assay	12356876	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12812758	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to auditory stimulus	IEP IEP: Inferred from expression pattern	19774669	RGD
involved in synaptic transmission, GABAergic	IDA IDA: Inferred from direct assay	12356876	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	21073549	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	15474980	RGD
located in inhibitory synapse	IDA IDA: Inferred from direct assay	20417281	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	9464994	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	21073549	RGD
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	21073549	RGD
located in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	9464994	RGD
located in sperm head	IDA IDA: Inferred from direct assay	15474980	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	12812758	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gamma-aminobutyric acid receptor subunit beta-3

GABA(A) receptor subunit beta-3	GABA-alpha receptor beta-3 subunit
Gamma-aminobutyric acid receptor beta 3	gamma-aminobutyric acid (GABA) A receptor, beta 3
gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3	gamma-aminobutyric acid type A rece

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05217	GABRB3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gabrb3	NCBI	NCBI:2562

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