Slc12a1 - solute carrier family 12 member 1 Gene

Also Known as BSC1; Nkcc2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25065

Summary

Enables sodium:potassium:chloride symporter activity. Involved in several processes, including chloride transport; metal ion transport; and protein insertion into membrane from inner side. Located in apical plasma membrane and cell surface. Human ortholog(s) of this gene implicated in Bartter disease and Bartter disease type 1. Orthologous to human SLC12A1 (solute carrier family 12 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc12a1 Products (2)

mRNA Protein Name
NM_001270617.1 NP_001257546.1 solute carrier family 12 member 1 isoform 1
NM_001270618.1 NP_001257547.1 solute carrier family 12 member 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables sodium:potassium:chloride symporter activity IDA
IDA: Inferred from direct assay
16291577 RGD
Biological Process GO Annotation Evidence References Source
involved in chloride transport IDA
IDA: Inferred from direct assay
16291577 RGD
involved in diterpenoid metabolic process IEP
IEP: Inferred from expression pattern
19592485 RGD
involved in monoatomic ion transmembrane transport IDA
IDA: Inferred from direct assay
16275913 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
16291577 RGD
involved in protein insertion into membrane from inner side IDA
IDA: Inferred from direct assay
19592485 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
16291577 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
19592485 RGD
located in cell surface IDA
IDA: Inferred from direct assay
19592485 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

solute carrier family 12 member 1

  • Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter)

  • bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1

  • bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2

  • kidney-specific Na-K-C

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12996 SLC12A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22029 Slc12a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc12a1 NCBI NCBI:6557