Scnn1a - sodium channel epithelial 1 subunit alpha Gene

Also Known as ENaCA

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25122

Summary

Enables WW domain binding activity; actin binding activity; and ligand-gated Sodium Channel activity. Contributes to sodium ion transmembrane transporter activity. Involved in regulation of body fluid levels and sodium ion transport. Located in several cellular components, including acrosomal vesicle; apical plasma membrane; and sperm principal piece. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 2; and pseudohypoaldosteronism. Orthologous to human SCNN1A (Sodium Channel epithelial 1 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Scnn1a Products (1)

mRNA Protein Name
NM_031548.2 NP_113736.1 amiloride-sensitive sodium channel subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables WW domain binding IPI
IPI: Inferred from physical interaction
8665844 RGD
enables actin binding IDA
IDA: Inferred from direct assay
16356937 RGD
enables ligand-gated sodium channel activity IDA
IDA: Inferred from direct assay
16356937 RGD
contributes to ligand-gated sodium channel activity IMP
IMP: Inferred from mutant phenotype
9118951 RGD
contributes to sodium ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
8107805 RGD
Biological Process GO Annotation Evidence References Source
involved in intracellular sodium ion homeostasis IDA
IDA: Inferred from direct assay
17562820 RGD
involved in regulation of body fluid levels IMP
IMP: Inferred from mutant phenotype
16258001 RGD
involved in sodium ion import across plasma membrane IDA
IDA: Inferred from direct assay
17562820 RGD
involved in sodium ion transport IDA
IDA: Inferred from direct assay
16554417 RGD
Cellular Component GO Annotation Evidence References Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
29453757 RGD
located in apical plasma membrane IDA
IDA: Inferred from direct assay
9118951 RGD
located in cortical actin cytoskeleton IDA
IDA: Inferred from direct assay
16356937 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
29453757 RGD
located in sperm principal piece IDA
IDA: Inferred from direct assay
29453757 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

amiloride-sensitive sodium channel subunit alpha

  • SCNEA

  • alpha-ENaC

  • alpha-NaCH

  • amiloride-sensitive epithelial sodium channel alpha subunit

  • epithelial Na(+) channel subunit alpha

  • epithelial sodium channel alpha subunit

  • nonvoltage-gated sodium channel 1 subunit alpha

  • sodium channel epithelial 1 alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12552 SCNN1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scnn1a NCBI NCBI:6337