Scnn1a - sodium channel epithelial 1 subunit alpha Gene

Rattus norvegicus

Also known as ENaCA

Gene ID: 25122 | Gene type: protein coding

About Scnn1a

Summary

Enables WW domain binding activity; actin binding activity; and ligand-gated Sodium Channel activity. Contributes to sodium ion transmembrane transporter activity. Involved in regulation of body fluid levels and sodium ion transport. Located in several cellular components, including acrosomal vesicle; apical plasma membrane; and sperm principal piece. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 2; and pseudohypoaldosteronism. Orthologous to human SCNN1A (Sodium Channel epithelial 1 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Scnn1a Products(1)

mRNA	Protein	Name
NM_031548.2	NP_113736.1	amiloride-sensitive sodium channel subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables WW domain binding	IPI IPI: Inferred from physical interaction	8665844	RGD
enables actin binding	IDA IDA: Inferred from direct assay	16356937	RGD
enables ligand-gated sodium channel activity	IDA IDA: Inferred from direct assay	16356937	RGD
contributes to ligand-gated sodium channel activity	IMP IMP: Inferred from mutant phenotype	9118951	RGD
contributes to sodium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	8107805	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular sodium ion homeostasis	IDA IDA: Inferred from direct assay	17562820	RGD
involved in regulation of body fluid levels	IMP IMP: Inferred from mutant phenotype	16258001	RGD
involved in sodium ion import across plasma membrane	IDA IDA: Inferred from direct assay	17562820	RGD
involved in sodium ion transport	IDA IDA: Inferred from direct assay	16554417	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	29453757	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	9118951	RGD
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	16356937	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	29453757	RGD
located in sperm principal piece	IDA IDA: Inferred from direct assay	29453757	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

amiloride-sensitive sodium channel subunit alpha

SCNEA	alpha-ENaC
alpha-NaCH	amiloride-sensitive epithelial sodium channel alpha subunit
epithelial Na(+) channel subunit alpha	epithelial sodium channel alpha subunit
nonvoltage-gated sodium channel 1 subunit alpha	sodium channel epithelial 1 alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12552	SCNN1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scnn1a	NCBI	NCBI:6337

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