Kcnj8 - potassium inwardly-rectifying channel, subfamily J, member 8 Gene

Rattus norvegicus

Also known as Kir6.1; UKATP1; uKATP-1

Gene ID: 25472 | Gene type: protein coding

About Kcnj8

Summary

Enables ATP binding activity; inorganic cation transmembrane transporter activity; and sulfonylurea receptor binding activity. Involved in kidney development and potassium ion import across plasma membrane. Located in intracellular membrane-bounded organelle and sarcolemma. Part of inward rectifying Potassium Channel. Colocalizes with mitochondrion. Used to study hypertension. Biomarker of Parkinsonism and sciatic neuropathy. Orthologous to human KCNJ8 (potassium inwardly rectifying channel subfamily J member 8). [provided by Alliance of Genome Resources, Apr 2022]

Kcnj8 Products(1)

mRNA	Protein	Name
NM_017099.4	NP_058795.3	ATP-sensitive inward rectifier potassium channel 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	11956191	RGD
enables ATP-activated inward rectifier potassium channel activity	IDA IDA: Inferred from direct assay	7890693	RGD
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	28842488	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15499025	RGD
enables sulfonylurea receptor binding	IPI IPI: Inferred from physical interaction	20123112	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in inorganic cation transmembrane transport	IGI IGI: Inferred from genetic interaction	28842488	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	12466933	RGD
involved in potassium ion import across plasma membrane	IDA IDA: Inferred from direct assay	7890693	RGD
involved in potassium ion transport	IDA IDA: Inferred from direct assay	17097686	RGD
involved in potassium ion transport	IMP IMP: Inferred from mutant phenotype	16048905	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17883401	RGD
part of inward rectifying potassium channel	IDA IDA: Inferred from direct assay	17097686	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	17883401	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	15647111	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-sensitive inward rectifier potassium channel 8

Inwardly rectifying potassium channel gene, subfamily J-8 (ATP sensitive)	inward rectifier K(+) channel Kir6.1
inwardly rectifier K(+) channel Kir6.1	potassium channel, inwardly rectifying subfamily J member 8
potassium voltage-gated channel subfamily

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07150	KCNJ8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22588	Kcnj8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnj8	NCBI	NCBI:3764

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