Kcnj8 - potassium inwardly-rectifying channel, subfamily J, member 8 Gene

Also Known as Kir6.1; UKATP1; uKATP-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25472

Summary

Enables ATP binding activity; inorganic cation transmembrane transporter activity; and sulfonylurea receptor binding activity. Involved in kidney development and potassium ion import across plasma membrane. Located in intracellular membrane-bounded organelle and sarcolemma. Part of inward rectifying Potassium Channel. Colocalizes with mitochondrion. Used to study hypertension. Biomarker of Parkinsonism and sciatic neuropathy. Orthologous to human KCNJ8 (potassium inwardly rectifying channel subfamily J member 8). [provided by Alliance of Genome Resources, Apr 2022]

Kcnj8 Products (1)

mRNA Protein Name
NM_017099.4 NP_058795.3 ATP-sensitive inward rectifier potassium channel 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
11956191 RGD
enables ATP-activated inward rectifier potassium channel activity IDA
IDA: Inferred from direct assay
7890693 RGD
enables ATPase-coupled monoatomic cation transmembrane transporter activity IGI
IGI: Inferred from genetic interaction
28842488 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15499025 RGD
enables sulfonylurea receptor binding IPI
IPI: Inferred from physical interaction
20123112 RGD
Biological Process GO Annotation Evidence References Source
involved in inorganic cation transmembrane transport IGI
IGI: Inferred from genetic interaction
28842488 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
12466933 RGD
involved in potassium ion import across plasma membrane IDA
IDA: Inferred from direct assay
7890693 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
17097686 RGD
involved in potassium ion transport IMP
IMP: Inferred from mutant phenotype
16048905 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17883401 RGD
part of inward rectifying potassium channel IDA
IDA: Inferred from direct assay
17097686 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
17883401 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
15647111 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-sensitive inward rectifier potassium channel 8

  • Inwardly rectifying potassium channel gene, subfamily J-8 (ATP sensitive)

  • inward rectifier K(+) channel Kir6.1

  • inwardly rectifier K(+) channel Kir6.1

  • potassium channel, inwardly rectifying subfamily J member 8

  • potassium voltage-gated channel subfamily

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07150 KCNJ8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22588 Kcnj8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnj8 NCBI NCBI:3764