Oaz1 - ornithine decarboxylase antizyme 1 Gene

Rattus norvegicus

Also known as Oaz; ODCAC; ODC-Az

Gene ID: 25502 | Gene type: protein coding

About Oaz1

Summary

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]

Oaz1 Products(3)

mRNA	Protein	Name
NM_001297557.1	NP_001284486.1	ornithine decarboxylase antizyme 1 isoform 2
NM_001301048.1	NP_001287977.1	ornithine decarboxylase antizyme 1 isoform 3
NM_139081.2	NP_620781.1	ornithine decarboxylase antizyme 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IDA IDA: Inferred from direct assay	12359729	RGD
enables ornithine decarboxylase inhibitor activity	IDA IDA: Inferred from direct assay	12359729	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	12359729	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to leptomycin B	IDA IDA: Inferred from direct assay	12941943	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	11880311	RGD
involved in cellular response to oxygen-glucose deprivation	IEP IEP: Inferred from expression pattern	19531214	RGD
involved in cellular response to polyamine macromolecule	IDA IDA: Inferred from direct assay	8166639	RGD
involved in negative regulation of ornithine catabolic process	IDA IDA: Inferred from direct assay	8166639	RGD
involved in negative regulation of polyamine transmembrane transport	IMP IMP: Inferred from mutant phenotype	8166639	RGD
involved in positive regulation of proteasomal protein catabolic process	IDA IDA: Inferred from direct assay	12359729	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	8649218	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12941943	RGD
located in nucleus	IDA IDA: Inferred from direct assay	12941943	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ornithine decarboxylase antizyme 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09732	OAZ1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Oaz1	NCBI	NCBI:4946

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