PCP4 - Pcp4 Purkinje cell protein 4 Gene

Also Known as PEPZ19; pep-19

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25510

Summary

The protein encoded by this gene regulates H1˚ and H3.3 histone synthesis by binding to H1˚ and H3.3 histone mRNAs. The encoded protein can bind Calmodulin as well, providung a possible link between calcium-dependent signals and histone metabolism. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

PCP4 Products (2)

mRNA Protein Name
NM_001270538.2 NP_001257467.1 calmodulin regulator protein PCP4 isoform LPI
NM_013002.4 NP_037134.1 calmodulin regulator protein PCP4 isoform PEP19

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
22020791 RGD
enables calmodulin binding IDA
IDA: Inferred from direct assay
10751438 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to L-glutamate IEP
IEP: Inferred from expression pattern
18502590 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
11117479 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
21671256 RGD
involved in negative regulation of protein kinase activity IDA
IDA: Inferred from direct assay
10751438 RGD
involved in osteoblast differentiation IEP
IEP: Inferred from expression pattern
18008138 RGD
involved in positive regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
21671256 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
21671256 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
10556647 RGD
located in neurofilament IDA
IDA: Inferred from direct assay
10556647 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calmodulin regulator protein PCP4

  • Neuron specific protein PEP-19 (Purkinje cell protein 4)

  • brain-specific antigen PCP-4

  • brain-specific polypeptide PEP-19

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10168 PCP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10169 PCP4L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22273 Pcp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PCP4 NCBI NCBI:5121