Slc34a1 - solute carrier family 34 member 1 Gene

Rattus norvegicus

Also known as Npt2; NaPi-2; NaPi2A; Slc17a2

Gene ID: 25548 | Gene type: protein coding

About Slc34a1

Summary

Enables PDZ domain binding activity and identical protein binding activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; ion transmembrane transport; and regulation of phosphate transport. Located in several cellular components, including apical plasma membrane; brush border membrane; and membrane raft. Is intrinsic component of plasma membrane. Biomarker of autosomal dominant polycystic kidney disease; chronic kidney disease (multiple); hyperthyroidism; hypophosphatemia; and hypothyroidism. Human ortholog(s) of this gene implicated in several diseases, including Fanconi syndrome (multiple); chronic kidney disease; hereditary hypophosphatemic rickets with hypercalciuria; hypophosphatemic nephrolithiasis/osteoporosis 1; and nephrolithiasis. Orthologous to human SLC34A1 (solute carrier family 34 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc34a1 Products(1)

mRNA	Protein	Name
NM_013030.2	NP_037162.1	sodium-dependent phosphate transport protein 2A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	15917299	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	9163330	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	21372499	RGD
enables sodium:phosphate symporter activity	IDA IDA: Inferred from direct assay	8327470	RGD
enables sodium:phosphate symporter activity	IMP IMP: Inferred from mutant phenotype	10926678	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in arsenate ion transmembrane transport	IDA IDA: Inferred from direct assay	20510259	RGD
involved in cellular response to metal ion	IEP IEP: Inferred from expression pattern	16476458	RGD
involved in cellular response to parathyroid hormone stimulus	IEP IEP: Inferred from expression pattern	16767692	RGD
involved in cellular response to phosphate starvation	IDA IDA: Inferred from direct assay	9058191	RGD
involved in cellular response to staurosporine	IEP IEP: Inferred from expression pattern	10332085	RGD
involved in dentinogenesis	IEP IEP: Inferred from expression pattern	12369784	RGD
involved in gentamycin metabolic process	IEP IEP: Inferred from expression pattern	11231357	RGD
involved in glycoprotein metabolic process	IEP IEP: Inferred from expression pattern	19005008	RGD
involved in indole metabolic process	IEP IEP: Inferred from expression pattern	10332085	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	10405196	RGD
involved in ossification	IEP IEP: Inferred from expression pattern	17310099	RGD
involved in phosphate ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	8327470	RGD
involved in positive regulation of membrane potential	IDA IDA: Inferred from direct assay	11880379	RGD
involved in positive regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	11880330	RGD
involved in positive regulation of phosphate transmembrane transport	IDA IDA: Inferred from direct assay	20236253	RGD
involved in positive regulation of sodium-dependent phosphate transport	IDA IDA: Inferred from direct assay	12739158	RGD
involved in positive regulation of sodium-dependent phosphate transport	IEP IEP: Inferred from expression pattern	16476458	RGD
involved in positive regulation of sodium-dependent phosphate transport	IMP IMP: Inferred from mutant phenotype	11880379	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	18305465	RGD
involved in response to growth hormone	IEP IEP: Inferred from expression pattern	14996669	RGD
involved in response to magnesium ion	IEP IEP: Inferred from expression pattern	18701629	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	10027934	RGD
involved in response to parathyroid hormone	IEP IEP: Inferred from expression pattern	20526720	RGD
involved in response to peptide	IEP IEP: Inferred from expression pattern	11532101	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	15581846	RGD
involved in response to potassium ion	IEP IEP: Inferred from expression pattern	19493963	RGD
involved in response to thyroid hormone	IEP IEP: Inferred from expression pattern	10098486	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	20507281	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	22260362	RGD
involved in sodium ion import across plasma membrane	IDA IDA: Inferred from direct assay	8327470	RGD
involved in sodium-dependent phosphate transport	IEP IEP: Inferred from expression pattern	17310099	RGD
involved in tricarboxylic acid metabolic process	IEP IEP: Inferred from expression pattern	10926678	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	9639577	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	8691716	RGD
located in cell surface	IDA IDA: Inferred from direct assay	21865732	RGD
located in endosome	IDA IDA: Inferred from direct assay	16514432	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10449440	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	10370077	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium-dependent phosphate transport protein 2A

Na(+)-dependent phosphate cotransporter 2A	Na(+)/Pi cotransporter 2A
naPi-2a	sodium-phosphate co-transporter type II
sodium-phosphate transport protein 2A	sodium/phosphate cotransporter 2A
solute carrier family 17 (sodium/hydrogen exchanger) member

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112065	PF-06869206	Inhibitor	99.88%	Unkown
HY-RS13192	SLC34A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc34a1	NCBI	NCBI:6569

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