Slc18a2 - solute carrier family 18 member A2 Gene

Also Known as MNAT; VMAT2; VMAT-2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25549

Summary

Enables several functions, including amine transmembrane transporter activity; enzyme binding activity; and heat shock protein binding activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; response to herbicide; and serotonin uptake. Located in neuronal cell body; secretory vesicle; and terminal bouton. Is active in dopaminergic synapse; neuronal dense core vesicle; and postsynapse. Is integral component of neuronal dense core vesicle membrane and integral component of synaptic vesicle membrane. Used to study Parkinson's disease and type 1 diabetes mellitus. Biomarker of Machado-Joseph disease; Parkinson's disease; substance-related disorder; and toxic encephalopathy. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human SLC18A2 (solute carrier family 18 member A2). [provided by Alliance of Genome Resources, Apr 2022]

Slc18a2 Products (1)

mRNA Protein Name
NM_013031.2 NP_037163.1 synaptic vesicular amine transporter

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amine transmembrane transporter activity IDA
IDA: Inferred from direct assay
1505023 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
19903816 RGD
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
19457116 RGD
enables heterocyclic compound binding IPI
IPI: Inferred from physical interaction
20007701 RGD
enables monoamine:proton antiporter activity IDA
IDA: Inferred from direct assay
8125935 RGD
Biological Process GO Annotation Evidence References Source
involved in aminergic neurotransmitter loading into synaptic vesicle IMP
IMP: Inferred from mutant phenotype
19903816 RGD
involved in cellular response to ammonium ion IEP
IEP: Inferred from expression pattern
20534840 RGD
involved in cellular response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
20007701 RGD
involved in endocytic recycling IEP
IEP: Inferred from expression pattern
20534840 RGD
involved in histamine uptake IDA
IDA: Inferred from direct assay
8860238 RGD
involved in insulin secretion IDA
IDA: Inferred from direct assay
18577569 RGD
involved in monoamine transport IDA
IDA: Inferred from direct assay
1438304 RGD
involved in negative regulation of neurotransmitter transport IMP
IMP: Inferred from mutant phenotype
16926160 RGD
involved in neurotransmitter transport IDA
IDA: Inferred from direct assay
19008227 RGD
involved in response to amphetamine IEP
IEP: Inferred from expression pattern
21159748 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
19038779 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
19494803 RGD
involved in response to herbicide IEP
IEP: Inferred from expression pattern
20553223 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
20224926 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
17536021 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18992277 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
20553223 RGD
involved in serotonin uptake IDA
IDA: Inferred from direct assay
8125935 RGD
involved in serotonin uptake IMP
IMP: Inferred from mutant phenotype
20007701 RGD
involved in somato-dendritic dopamine secretion IDA
IDA: Inferred from direct assay
16301178 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
16301178 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
18973576 RGD
located in cell body IDA
IDA: Inferred from direct assay
18973576 RGD
located in cell projection IDA
IDA: Inferred from direct assay
21342027 RGD
located in dendrite IDA
IDA: Inferred from direct assay
16301178 RGD
located in dense core granule IDA
IDA: Inferred from direct assay
7568015 RGD
is active in dopaminergic synapse IDA
IDA: Inferred from direct assay
8753875 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
19457116 RGD
is active in neuronal dense core vesicle IDA
IDA: Inferred from direct assay
8753875 RGD
is active in neuronal dense core vesicle membrane IDA
IDA: Inferred from direct assay
7568015 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
8753875 RGD
located in secretory granule membrane IDA
IDA: Inferred from direct assay
16301178 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
7568015 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
8753875 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
16301178 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
20534840 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptic vesicular amine transporter

  • Solute carrier family 18 A2 (vesicular monoamine transporter 2)

  • VAT2

  • monoamine transporter

  • solute carrier family 18 (vesicular monoamine transporter), member 2

  • solute carrier family 18 (vesicular monoamine), member 2

  • solute carrier family 18 member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13044 SLC18A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22032 Slc18a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc18a2 NCBI NCBI:6571