Slc18a2 - solute carrier family 18 member A2 Gene

Rattus norvegicus

Also known as MNAT; VMAT2; VMAT-2

Gene ID: 25549 | Gene type: protein coding

About Slc18a2

Summary

Enables several functions, including amine transmembrane transporter activity; enzyme binding activity; and heat shock protein binding activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; response to herbicide; and serotonin uptake. Located in neuronal cell body; secretory vesicle; and terminal bouton. Is active in dopaminergic synapse; neuronal dense core vesicle; and postsynapse. Is integral component of neuronal dense core vesicle membrane and integral component of synaptic vesicle membrane. Used to study Parkinson's disease and type 1 diabetes mellitus. Biomarker of Machado-Joseph disease; Parkinson's disease; substance-related disorder; and toxic encephalopathy. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human SLC18A2 (solute carrier family 18 member A2). [provided by Alliance of Genome Resources, Apr 2022]

Slc18a2 Products(1)

mRNA	Protein	Name
NM_013031.2	NP_037163.1	synaptic vesicular amine transporter

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amine transmembrane transporter activity	IDA IDA: Inferred from direct assay	1505023	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	19903816	RGD
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	19457116	RGD
enables heterocyclic compound binding	IPI IPI: Inferred from physical interaction	20007701	RGD
enables monoamine:proton antiporter activity	IDA IDA: Inferred from direct assay	8125935	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in aminergic neurotransmitter loading into synaptic vesicle	IMP IMP: Inferred from mutant phenotype	19903816	RGD
involved in cellular response to ammonium ion	IEP IEP: Inferred from expression pattern	20534840	RGD
involved in cellular response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	20007701	RGD
involved in endocytic recycling	IEP IEP: Inferred from expression pattern	20534840	RGD
involved in histamine uptake	IDA IDA: Inferred from direct assay	8860238	RGD
involved in insulin secretion	IDA IDA: Inferred from direct assay	18577569	RGD
involved in monoamine transport	IDA IDA: Inferred from direct assay	1438304	RGD
involved in negative regulation of neurotransmitter transport	IMP IMP: Inferred from mutant phenotype	16926160	RGD
involved in neurotransmitter transport	IDA IDA: Inferred from direct assay	19008227	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	21159748	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	19038779	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	19494803	RGD
involved in response to herbicide	IEP IEP: Inferred from expression pattern	20553223	RGD
involved in response to metal ion	IEP IEP: Inferred from expression pattern	20224926	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	17536021	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18992277	RGD
involved in response to zinc ion	IEP IEP: Inferred from expression pattern	20553223	RGD
involved in serotonin uptake	IDA IDA: Inferred from direct assay	8125935	RGD
involved in serotonin uptake	IMP IMP: Inferred from mutant phenotype	20007701	RGD
involved in somato-dendritic dopamine secretion	IDA IDA: Inferred from direct assay	16301178	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	16301178	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	18973576	RGD
located in cell body	IDA IDA: Inferred from direct assay	18973576	RGD
located in cell projection	IDA IDA: Inferred from direct assay	21342027	RGD
located in dendrite	IDA IDA: Inferred from direct assay	16301178	RGD
located in dense core granule	IDA IDA: Inferred from direct assay	7568015	RGD
is active in dopaminergic synapse	IDA IDA: Inferred from direct assay	8753875	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	19457116	RGD
is active in neuronal dense core vesicle	IDA IDA: Inferred from direct assay	8753875	RGD
is active in neuronal dense core vesicle membrane	IDA IDA: Inferred from direct assay	7568015	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	8753875	RGD
located in secretory granule membrane	IDA IDA: Inferred from direct assay	16301178	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	7568015	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	8753875	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	16301178	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	20534840	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

synaptic vesicular amine transporter

Solute carrier family 18 A2 (vesicular monoamine transporter 2)	VAT2
monoamine transporter	solute carrier family 18 (vesicular monoamine transporter), member 2
solute carrier family 18 (vesicular monoamine), member 2	solute carrier family 18 member 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13044	SLC18A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22032	Slc18a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc18a2	NCBI	NCBI:6571

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