GABRP - gamma-aminobutyric acid type A receptor subunit pi Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2568

About GABRP

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:170,782,720-170,814,047 (from NCBI)

This gene has 10 transcripts (splice variants), 124 orthologues and 45 paralogues. Biased expression in esophagus (RPKM 45.1), endometrium (RPKM 30.6) and 5 other tissues.

Summary

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit Chloride Channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

GABRP Products (2)

mRNA Protein Name
NM_001291985.2 NP_001278914.1 gamma-aminobutyric acid receptor subunit pi isoform 2 precursor
NM_014211.3 NP_055026.1 gamma-aminobutyric acid receptor subunit pi isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables GABA-A receptor activity IDA
IDA: Inferred from direct assay
10462548 GOA
enables GABA-gated chloride ion channel activity IDA
IDA: Inferred from direct assay
10462548 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GABRP Protein Structure

Neur_chan_LBD

Neur_chan_LBD: Neurotransmitter-gated ion-channel ligand binding domain (42 - 241)

Neur_chan_memb

Neur_chan_memb: Neurotransmitter-gated ion-channel transmembrane region (249 - 356)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit pi

  • GABA(A) receptor subunit pi

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05223 GABRP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20412 Gabrp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26921 Gabrp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GABRP MGD MGI:2387597
Rattus norvegicus GABRP RGD RGD:620532
Macaca mulatta GABRP VGNC VGNC:72859
Felis catus GABRP VGNC VGNC:62428
Bos taurus GABRP VGNC VGNC:29201
Canis familiaris GABRP VGNC VGNC:41065
Others GABRP NCBI