GABRP - gamma-aminobutyric acid type A receptor subunit pi Gene

Homo sapiens

Gene ID: 2568 | Gene type: protein coding

About GABRP

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:170,782,720-170,814,047 (from NCBI)

This gene has 10 transcripts (splice variants), 124 orthologues and 45 paralogues. Biased expression in esophagus (RPKM 45.1), endometrium (RPKM 30.6) and 5 other tissues.

Summary

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit Chloride Channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

GABRP Products(2)

mRNA	Protein	Name
NM_001291985.2	NP_001278914.1	gamma-aminobutyric acid receptor subunit pi isoform 2 precursor
NM_014211.3	NP_055026.1	gamma-aminobutyric acid receptor subunit pi isoform 1 precursor

GABRP Protein Structure

Neur_chan_LBD

Neur_chan_memb

0
100
200
300
400
440 a.a.

Protein Preferred Names

Protein Names

gamma-aminobutyric acid receptor subunit pi

GABA(A) receptor subunit pi

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05223	GABRP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GABRP	MGD	MGI:2387597
Rattus norvegicus	GABRP	RGD	RGD:620532
Macaca mulatta	GABRP	VGNC	VGNC:72859
Felis catus	GABRP	VGNC	VGNC:62428
Bos taurus	GABRP	VGNC	VGNC:29201
Canis familiaris	GABRP	VGNC	VGNC:41065

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