Vldlr - very low density lipoprotein receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25696

Summary

Predicted to enable several functions, including reelin receptor activity; very-low-density lipoprotein particle binding activity; and very-low-density lipoprotein particle receptor activity. Involved in several processes, including cellular response to glucose starvation; cellular response to interleukin-1; and cellular response to lipopolysaccharide. Located in several cellular components, including apical part of cell; cell surface; and perinuclear region of cytoplasm. Biomarker of focal segmental glomerulosclerosis and nephrotic syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease; cerebellar ataxia, mental retardation and dysequlibrium syndrome; and dementia. Orthologous to human VLDLR (very low density lipoprotein receptor). [provided by Alliance of Genome Resources, Apr 2022]

Vldlr Products (1)

mRNA Protein Name
NM_013155.2 NP_037287.2 very low-density lipoprotein receptor precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose starvation IEP
IEP: Inferred from expression pattern
18262491 RGD
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
19233325 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
15878964 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
16376325 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
16376325 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
20368265 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
12051760 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
7929362 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
15942958 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
16376325 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
11882325 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19359144 RGD
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
19946030 RGD
located in cell surface IDA
IDA: Inferred from direct assay
19233325 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19233325 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

very low-density lipoprotein receptor

  • VLDL receptor

  • VLDL-R

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15661 VLDLR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18002 Vldlr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24474 Vldlr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990143 Anti-Mouse/Rat/Bovine VLDL-R Antibody (IgG-6A6) Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vldlr NCBI NCBI:7436
Mus musculus Vldlr NCBI NCBI:22359