Kcnb1 - potassium voltage-gated channel subfamily B member 1 Gene

Also Known as Shab; Kv2.1; DRK1PC; Kcr1-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25736

Summary

Enables several functions, including protein heterodimerization activity; transmembrane transporter binding activity; and voltage-gated Potassium Channel activity. Involved in several processes, including positive regulation of transport; potassium ion export across plasma membrane; and regulation of motor neuron apoptotic process. Acts upstream of or within potassium ion transport. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and perikaryon. Part of voltage-gated Potassium Channel complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26 and epilepsy. Orthologous to human KCNB1 (potassium voltage-gated channel subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnb1 Products (1)

mRNA Protein Name
NM_013186.3 NP_037318.2 potassium voltage-gated channel subfamily B member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNARE binding IPI
IPI: Inferred from physical interaction
19077057 RGD
NOT enables delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
8980147 RGD
enables delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
1875913 RGD
enables delayed rectifier potassium channel activity IMP
IMP: Inferred from mutant phenotype
9545040 RGD
enables outward rectifier potassium channel activity IMP
IMP: Inferred from mutant phenotype
12127166 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12954870 RGD
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
20202934 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
20202934 RGD
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
15046870 RGD
Biological Process GO Annotation Evidence References Source
involved in action potential IDA
IDA: Inferred from direct assay
20484665 RGD
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
8978827 RGD
involved in cellular response to nutrient levels IDA
IDA: Inferred from direct assay
19077057 RGD
involved in clustering of voltage-gated potassium channels IDA
IDA: Inferred from direct assay
24355600 RGD
involved in glutamate receptor signaling pathway IDA
IDA: Inferred from direct assay
19077057 RGD
involved in positive regulation of calcium ion-dependent exocytosis IDA
IDA: Inferred from direct assay
17301173 RGD
involved in positive regulation of catecholamine secretion IDA
IDA: Inferred from direct assay
20484665 RGD
involved in positive regulation of norepinephrine secretion IDA
IDA: Inferred from direct assay
18167541 RGD
involved in positive regulation of protein targeting to membrane IDA
IDA: Inferred from direct assay
12954870 RGD
involved in potassium ion export across plasma membrane IMP
IMP: Inferred from mutant phenotype
12127166 RGD
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
8980147 RGD
acts upstream of or within potassium ion transport IDA
IDA: Inferred from direct assay
15046870 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
8189205 RGD
involved in potassium ion transport IMP
IMP: Inferred from mutant phenotype
9545040 RGD
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
9305895 RGD
involved in regulation of motor neuron apoptotic process IDA
IDA: Inferred from direct assay
19077057 RGD
involved in response to L-glutamate IEP
IEP: Inferred from expression pattern
24355600 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
24355600 RGD
involved in vesicle docking involved in exocytosis IDA
IDA: Inferred from direct assay
20484665 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IMP
IMP: Inferred from mutant phenotype
8978827 RGD
located in axon IDA
IDA: Inferred from direct assay
19014551 RGD
located in cell surface IDA
IDA: Inferred from direct assay
8978827 RGD
is active in cholinergic synapse IDA
IDA: Inferred from direct assay
14608003 RGD
located in dendrite IDA
IDA: Inferred from direct assay
8463836 RGD
located in dendrite membrane IDA
IDA: Inferred from direct assay
14608003 RGD
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
8978827 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8463836 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
8978827 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
12954870 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
8978827 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
9305895 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
14608003 RGD
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
14608003 RGD
located in proximal dendrite IDA
IDA: Inferred from direct assay
8978827 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
8980147 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily B member 1

  • DRK1

  • delayed rectifier potassium channel 1

  • potassium channel Kv2.1

  • potassium channel, voltage gated Shab-related subfamily B, member 1

  • potassium voltage gated channel, Shab-related subfamily, member 1

  • voltage-gated potassium channel subunit Kv2.1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07106 KCNB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnb1 NCBI NCBI:3745