Kcnb1 - potassium voltage-gated channel subfamily B member 1 Gene

Rattus norvegicus

Also known as Shab; Kv2.1; DRK1PC; Kcr1-1

Gene ID: 25736 | Gene type: protein coding

About Kcnb1

Summary

Enables several functions, including protein heterodimerization activity; transmembrane transporter binding activity; and voltage-gated Potassium Channel activity. Involved in several processes, including positive regulation of transport; potassium ion export across plasma membrane; and regulation of motor neuron apoptotic process. Acts upstream of or within potassium ion transport. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and perikaryon. Part of voltage-gated Potassium Channel complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26 and epilepsy. Orthologous to human KCNB1 (potassium voltage-gated channel subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnb1 Products(1)

mRNA	Protein	Name
NM_013186.3	NP_037318.2	potassium voltage-gated channel subfamily B member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IPI IPI: Inferred from physical interaction	19077057	RGD
NOT enables delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	8980147	RGD
enables delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	1875913	RGD
enables delayed rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	9545040	RGD
enables outward rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	12127166	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12954870	RGD
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	20202934	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	20202934	RGD
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	15046870	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in action potential	IDA IDA: Inferred from direct assay	20484665	RGD
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	8978827	RGD
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	19077057	RGD
involved in clustering of voltage-gated potassium channels	IDA IDA: Inferred from direct assay	24355600	RGD
involved in glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	19077057	RGD
involved in positive regulation of calcium ion-dependent exocytosis	IDA IDA: Inferred from direct assay	17301173	RGD
involved in positive regulation of catecholamine secretion	IDA IDA: Inferred from direct assay	20484665	RGD
involved in positive regulation of norepinephrine secretion	IDA IDA: Inferred from direct assay	18167541	RGD
involved in positive regulation of protein targeting to membrane	IDA IDA: Inferred from direct assay	12954870	RGD
involved in potassium ion export across plasma membrane	IMP IMP: Inferred from mutant phenotype	12127166	RGD
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	8980147	RGD
acts upstream of or within potassium ion transport	IDA IDA: Inferred from direct assay	15046870	RGD
involved in potassium ion transport	IDA IDA: Inferred from direct assay	8189205	RGD
involved in potassium ion transport	IMP IMP: Inferred from mutant phenotype	9545040	RGD
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	9305895	RGD
involved in regulation of motor neuron apoptotic process	IDA IDA: Inferred from direct assay	19077057	RGD
involved in response to L-glutamate	IEP IEP: Inferred from expression pattern	24355600	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	24355600	RGD
involved in vesicle docking involved in exocytosis	IDA IDA: Inferred from direct assay	20484665	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IMP IMP: Inferred from mutant phenotype	8978827	RGD
located in axon	IDA IDA: Inferred from direct assay	19014551	RGD
located in cell surface	IDA IDA: Inferred from direct assay	8978827	RGD
is active in cholinergic synapse	IDA IDA: Inferred from direct assay	14608003	RGD
located in dendrite	IDA IDA: Inferred from direct assay	8463836	RGD
located in dendrite membrane	IDA IDA: Inferred from direct assay	14608003	RGD
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	8978827	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	8463836	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	8978827	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	12954870	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	8978827	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	9305895	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	14608003	RGD
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	14608003	RGD
located in proximal dendrite	IDA IDA: Inferred from direct assay	8978827	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	8980147	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily B member 1

DRK1	delayed rectifier potassium channel 1
potassium channel Kv2.1	potassium channel, voltage gated Shab-related subfamily B, member 1
potassium voltage gated channel, Shab-related subfamily, member 1	voltage-gated potassium channel subunit Kv2.1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07106	KCNB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnb1	NCBI	NCBI:3745

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