SLC24A2 - solute carrier family 24 member 2 Gene

Also Known as NCKX2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25769

About SLC24A2

Cytogenetic location: 9p22.1-p21.3 Genomic coordinates (GRCh38): 9:19,507,455-20,307,892 (from NCBI)

This gene has 2 transcripts (splice variants), 288 orthologues and 4 paralogues. Restricted expression toward brain (RPKM 17.5).

Summary

This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

SLC24A2 Products (4)

mRNA	Protein	Name
NM_001193288.3	NP_001180217.1	sodium/potassium/calcium exchanger 2 isoform 2
NM_001375850.1	NP_001362779.1	sodium/potassium/calcium exchanger 2 isoform 1
NM_001375851.1	NP_001362780.1	sodium/potassium/calcium exchanger 2 isoform 2
NM_020344.4	NP_065077.1	sodium/potassium/calcium exchanger 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium, potassium:sodium antiporter activity	IDA IDA: Inferred from direct assay	10662833	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in calcium ion import	IDA IDA: Inferred from direct assay	27093457	GOA
involved in calcium ion import across plasma membrane	IDA IDA: Inferred from direct assay	10662833	GOA
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	26631410	GOA
acts upstream of or within intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	26631410	GOA
acts upstream of or within monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	18166528	GOA
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	26631410	GOA
involved in sodium ion transmembrane transport	IDA IDA: Inferred from direct assay	26631410	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	26631410	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC24A2 Protein Structure

Na_Ca_ex

0
200
400
600
661 a.a.

Protein Preferred Names	Protein Names
sodium/potassium/calcium exchanger 2	Na(+)/K(+)/Ca(2+)-exchange protein 2

Related Diseases

Diseases	Alias
Epilepsy, Familial Temporal Lobe, 5	Familial Temporal Lobe Epilepsy 5 ETL5 Epilepsy, Temporal Lobe, Familial, Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13085	SLC24A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13087	SLC24A4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC24A2	RGD	RGD:628650
Mus musculus	SLC24A2	MGD	MGI:1923626
Macaca mulatta	SLC24A2	VGNC	VGNC:77425
Felis catus	SLC24A2	VGNC	VGNC:65249
Bos taurus	SLC24A2	VGNC	VGNC:34737
Canis familiaris	SLC24A2	VGNC	VGNC:46286
Others	SLC24A2	NCBI