DCAF12 - DDB1 and CUL4 associated factor 12 Gene

Also Known as CT102; TCC52; WDR40A; KIAA1892

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25853

About DCAF12

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,086,387-34,126,698 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 2 paralogues. Broad expression in testis (RPKM 38.2), lymph node (RPKM 19.3) and 25 other tissues.

Summary

This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 Ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]

DCAF12 Products (1)

mRNA Protein Name
NM_015397.4 NP_056212.1 DDB1- and CUL4-associated factor 12

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16949367 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
29779948 GOA
Biological Process GO Annotation Evidence References Source
involved in T cell activation IDA
IDA: Inferred from direct assay
34065512 GOA
acts upstream of regulation of autophagy IDA
IDA: Inferred from direct assay
31267705 GOA
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IDA
IDA: Inferred from direct assay
29779948 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul4-RING E3 ubiquitin ligase complex IDA
IDA: Inferred from direct assay
29779948 GOA
part of Cul4-RING E3 ubiquitin ligase complex IMP
IMP: Inferred from mutant phenotype
16949367 GOA
located in centrosome IDA
IDA: Inferred from direct assay
18957058 GOA
is active in cytoplasm IDA
IDA: Inferred from direct assay
34065512 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
18957058 GOA
is active in cytosol IDA
IDA: Inferred from direct assay
34065512 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCAF12 Protein Structure

WD40

WD40: WD domain, G-beta repeat (181 - 211)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
Protein Preferred Names Protein Names

DDB1- and CUL4-associated factor 12

  • WD repeat domain 40A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03559 DCAF12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DCAF12 VGNC VGNC:61355
Bos taurus DCAF12 VGNC VGNC:27901
Mus musculus DCAF12 MGD MGI:1916220
Macaca mulatta DCAF12 VGNC VGNC:71678
Rattus norvegicus DCAF12 RGD RGD:1594034
Canis familiaris DCAF12 VGNC VGNC:39790
Others DCAF12 NCBI