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ZNF521 - zinc finger protein 521 Gene

Also Known as EHZF; Evi3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25925

About ZNF521

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:25,061,924-25,352,166 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues, 7 paralogues and is associated with 92 phenotypes. Ubiquitous expression in ovary (RPKM 5.8), spleen (RPKM 5.0) and 22 other tissues.

Summary

Enables protein domain specific binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within neuron fate commitment. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF521 Products (2)

mRNA	Protein	Name
NM_001308225.2	NP_001295154.1	zinc finger protein 521 isoform 2
NM_015461.3	NP_056276.1	zinc finger protein 521 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11984006	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	12393497	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF521 Protein Structure

zf-C2H2_6

zf-C2H2

zf-H2C2_2

zf-C2H2_4

zf-C2H2

zf-C2H2_4

zf-C2H2_6

zf-C2H2_4

zf-H2C2_2

zf-C2H2_6

zf-C2H2_4

0
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900
1200
1311 a.a.

Protein Preferred Names	Protein Names
zinc finger protein 521	LYST-interacting protein 3

Related Diseases

Diseases	Alias
Invasive Bladder Transitional Cell Carcinoma	Invasive Bladder Urothelial Carcinoma Infiltrating Bladder Urothelial Carcinoma
Gastrointestinal Neuroendocrine Benign Tumor
Gastric Neuroendocrine Neoplasm	Gastric Neuroendocrine Tumor Neuroendocrine Tumor Of The Stomach Neuroendocrine Tumor Of Stomach Gnet Gastric Net Net Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16151	ZNF521 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZNF521	VGNC	VGNC:79444
Bos taurus	ZNF521	VGNC	VGNC:37296
Mus musculus	ZNF521	MGD	MGI:95459
Felis catus	ZNF521	VGNC	VGNC:67321
Canis familiaris	ZNF521	VGNC	VGNC:48750
Rattus norvegicus	ZNF521	RGD	RGD:1307345