RNF167 - ring finger protein 167 Gene

Also Known as LP2254; RING105; 5730408C10Rik

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26001

About RNF167

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,940,092-4,945,222 (from NCBI)

This gene has 16 transcripts (splice variants), 121 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 26.0), thyroid (RPKM 24.0) and 25 other tissues.

Summary

RNF167 is an E3 ubiquitin Ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]

RNF167 Products (20)

mRNA	Protein	Name
NM_001320356.2	NP_001307285.1	E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320357.2	NP_001307286.1	E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320358.2	NP_001307287.1	E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320359.2	NP_001307288.1	E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320360.2	NP_001307289.1	E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320361.2	NP_001307290.1	E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320362.2	NP_001307291.1	E3 ubiquitin-protein ligase RNF167 isoform b
NM_001320363.2	NP_001307292.1	E3 ubiquitin-protein ligase RNF167 isoform b
NM_001320364.2	NP_001307293.1	E3 ubiquitin-protein ligase RNF167 isoform b
NM_001320365.2	NP_001307294.1	E3 ubiquitin-protein ligase RNF167 isoform b
NM_001370303.1	NP_001357232.1	E3 ubiquitin-protein ligase RNF167 isoform c precursor
NM_001370304.1	NP_001357233.1	E3 ubiquitin-protein ligase RNF167 isoform c precursor
NM_001370305.1	NP_001357234.1	E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001370306.1	NP_001357235.1	E3 ubiquitin-protein ligase RNF167 isoform d precursor
NM_001370307.1	NP_001357236.1	E3 ubiquitin-protein ligase RNF167 isoform d precursor
NM_001370308.1	NP_001357237.1	E3 ubiquitin-protein ligase RNF167 isoform e
NM_001370311.1	NP_001357240.1	E3 ubiquitin-protein ligase RNF167 isoform b
NM_001370313.1	NP_001357242.1	E3 ubiquitin-protein ligase RNF167 isoform f precursor
NM_001375485.1	NP_001362414.1	E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_015528.3	NP_056343.1	E3 ubiquitin-protein ligase RNF167 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16314844	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	23129617	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	16314844	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to leucine starvation	IDA IDA: Inferred from direct assay	35114100	GOA
acts upstream of lysosome localization	IDA IDA: Inferred from direct assay	32409562	GOA
involved in lysosome localization	IDA IDA: Inferred from direct assay	27808481	GOA
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	35114100	GOA
involved in negative regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	16314844	GOA
involved in organelle localization	IMP IMP: Inferred from mutant phenotype	24387786	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	33594058	GOA
involved in protein K29-linked ubiquitination	IDA IDA: Inferred from direct assay	33594058	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	35114100	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	16314844	GOA
involved in regulation of synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	23129617	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	27808481	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16314844	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	32409562	GOA
is active in endolysosome membrane	IDA IDA: Inferred from direct assay	23129617	GOA
located in endosome	IDA IDA: Inferred from direct assay	24387786	GOA
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	27808481	GOA
is active in lysosome	IDA IDA: Inferred from direct assay	27808481	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF167 Protein Structure

PA

zf-RING_2

0
100
200
300
350 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RNF167	RING-type E3 ubiquitin transferase RNF167

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 73	DEE73 Epileptic Encephalopathy, Early Infantile, 73 Eiee73 Developmental And Epileptic Encephalopathy, 73 Early Infantile Epileptic Encephalopathy 73 Rnf13-Related Severe Early-Onset Epileptic Encephalopathy Rnf13-Related Severe Eoee
Lissencephaly 8	LIS8
Spinocerebellar Ataxia, Autosomal Recessive 24	SCAR24 Autosomal Recessive Spinocerebellar Ataxia 24 Spinocerebellar Ataxia, Autosomal Recessive, 24 Ataxia, Spinocerebellar, Autosomal Recessive, Type 24

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12061	RNF167 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RNF167	VGNC	VGNC:76812
Mus musculus	RNF167	MGD	MGI:1917760
Rattus norvegicus	RNF167	RGD	RGD:1305972
Canis familiaris	RNF167	VGNC	VGNC:59031
Bos taurus	RNF167	VGNC	VGNC:57151