ACOT11 - acyl-CoA thioesterase 11 Gene

Also Known as BFIT; THEA; THEM1; STARD14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26027

About ACOT11

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:54,548,228-54,639,192 (from NCBI)

This gene has 5 transcripts (splice variants), 279 orthologues and 2 paralogues. Biased expression in kidney (RPKM 35.3), small intestine (RPKM 20.0) and 9 other tissues.

Summary

This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

ACOT11 Products (2)

mRNA Protein Name
NM_015547.4 NP_056362.1 acyl-coenzyme A thioesterase 11 isoform 1
NM_147161.4 NP_671517.1 acyl-coenzyme A thioesterase 11 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fatty acyl-CoA hydrolase activity IDA
IDA: Inferred from direct assay
22897136 GOA
enables long-chain fatty acyl-CoA hydrolase activity IDA
IDA: Inferred from direct assay
22897136 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22897136 GOA
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
22897136 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACOT11 Protein Structure

4HBT

4HBT: Thioesterase superfamily (67 - 133)

4HBT

4HBT: Thioesterase superfamily (234 - 303)

START

START: START domain (385 - 587)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 607 a.a.
Protein Preferred Names Protein Names

acyl-coenzyme A thioesterase 11

  • START domain containing 14

Related Diseases

Diseases Alias
Leukoencephalopathy With Vanishing White Matter

  • Cree Leukoencephalopathy

  • Vanishing White Matter Disease

  • Ovarioleukodystrophy

  • Vanishing White Matter Leukodystrophy

  • Childhood Ataxia With Central Nervous System Hypomyelinization

  • Cach

  • Cach Syndrome

  • Myelinosis Centralis Diffusa

  • VWM

  • Cle

  • Childhood Ataxia With Central Nervous System Hypomyelination

  • Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

  • Cach/Vwm

  • Cach/Vwm Syndrome

  • Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

  • Cree Leukoencehalopathy

  • Late Infantile Cach Syndrome

  • Juvenile Or Adult Cach Syndrome

  • Congenital Or Early Infantile Cach Syndrome

  • Leukodystrophy With Vanishing White Matter
Multiple Acyl-Coa Dehydrogenase Deficiency

  • MADD

  • Ethylmalonic-Adipicaciduria

  • Ema

  • Glutaric Acidemia Iia

  • Glutaric Acidemia Iib

  • Ga Ii

  • Glutaric Acidemia Iic

  • Glutaric Acidemia Type 2

  • Glutaric Acidemia Ii

  • Glutaric Aciduria Ii

  • Electron Transfer Flavoprotein Deficiency

  • Glutaric Aciduria Type 2

  • Mad Deficiency

  • Glutaric Acidemia Type Ii

  • Glutaric Aciduria 2

  • Etfa Deficiency

  • Etfb Deficiency

  • Etfdh Deficiency

  • Multiple Acyl Coenzyme A Dehydrogenase Deficiency

  • Ga2

  • Electron Transfer Flavoprotein Ubiquinone Oxidoreductase Deficiency

  • Electron Transfer Flavoprotein Dehydrogenase Deficiency

  • Ga 2

  • Glutaric Acidemia 2

  • Glutaric Acidemia, Type 2

  • Glutaric Aciduria, Type 2

  • Mad

  • Multiple Fad Dehydrogenase Deficiency

  • Ethylmalonic Adipic Aciduria

  • Glutaricaciduria Ii

  • Glutaric Aciduria 2a

  • GA2A

  • Gaiia

  • Glutaricaciduria Iia

  • Glutaric Aciduria 2b

  • GA2B

  • Gaiib

  • Glutaricaciduria Iib

  • Glutaric Aciduria 2c

  • GA2C

  • Gaiic

  • Glutaricaciduria Iic

  • Glutaricaciduria, Type Iia

  • Glutaric Acidemia Type 2a

  • Glutaric Acidemia Type 2c

  • Glutaric Aciduria Iia

  • Glutaric Aciduria Iib

  • Glutaric Aciduria Iic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00174 ACOT11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ACOT11 VGNC VGNC:59518
Rattus norvegicus ACOT11 RGD RGD:2324815
Mus musculus ACOT11 MGD MGI:1913736
Canis familiaris ACOT11 VGNC VGNC:37516
Bos taurus ACOT11 VGNC VGNC:25547
Macaca mulatta ACOT11 VGNC VGNC:69458
Others ACOT11 NCBI