Snx27 - sorting nexin 27 Gene

Also Known as Mrt1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 260323

Summary

Enables ionotropic glutamate receptor binding activity and phosphatidylinositol-3-phosphate binding activity. Involved in several processes, including endosome to plasma membrane protein transport; negative regulation of inward rectifier Potassium Channel activity; and positive regulation of AMPA glutamate receptor clustering. Located in several cellular components, including cytosol; early endosome; and postsynaptic density. Orthologous to human SNX27 (sorting nexin 27). [provided by Alliance of Genome Resources, Apr 2022]

Snx27 Products (2)

mRNA	Protein	Name
NM_001110151.1	NP_001103621.1	sorting nexin-27 isoform a
NM_152847.2	NP_690060.2	sorting nexin-27 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	34233182	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	25071192	RGD
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	17828261	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17828261	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	16076023	RGD
involved in endosomal transport	IMP IMP: Inferred from mutant phenotype	17828261	RGD
involved in endosome to plasma membrane protein transport	IMP IMP: Inferred from mutant phenotype	25136126	RGD
involved in establishment of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	25071192	RGD
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	17828261	RGD
involved in negative regulation of inward rectifier potassium channel activity	IDA IDA: Inferred from direct assay	21422294	RGD
involved in neurotransmitter receptor transport to plasma membrane	IMP IMP: Inferred from mutant phenotype	34233182	RGD
involved in positive regulation of AMPA glutamate receptor clustering	IMP IMP: Inferred from mutant phenotype	25071192	RGD
involved in response to methamphetamine hydrochloride	IEP IEP: Inferred from expression pattern	12740601	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome	IDA IDA: Inferred from direct assay	17828261	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sorting nexin-27	MAP-responsive gene protein PDZ-protein Mrt1 methamphetamine (MAP) responsive transcript 1 methamphetamine-responsive transcript 1 protein sorting nexin family member 27

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13537	SNX27 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Snx27	NCBI	NCBI:81609