ARHGEF26 - Rho guanine nucleotide exchange factor 26 Gene

Also Known as SGEF; CSGEF; HMFN1864

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26084

About ARHGEF26

Cytogenetic location: 3q25.2 Genomic coordinates (GRCh38): 3:154,121,003-154,257,825 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 189 orthologues and 6 paralogues. Broad expression in lung (RPKM 13.8), brain (RPKM 7.6) and 23 other tissues.

Summary

This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

ARHGEF26 Products (3)

mRNA Protein Name
NM_001251962.2 NP_001238891.1 rho guanine nucleotide exchange factor 26 isoform 1
NM_001251963.2 NP_001238892.1 rho guanine nucleotide exchange factor 26 isoform 2
NM_015595.4 NP_056410.3 rho guanine nucleotide exchange factor 26 isoform 1

ARHGEF26 Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (444 - 622)

PH

PH: PH domain (656 - 778)

SH3_1

SH3_1: SH3 domain (800 - 841)

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  • 200
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  • 800
  • 871 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 26

  • Rho guanine nucleotide exchange factor (GEF) 26

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00956 ARHGEF26 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARHGEF26 RGD RGD:1562559
Bos taurus ARHGEF26 VGNC VGNC:26113
Felis catus ARHGEF26 VGNC VGNC:59904
Canis familiaris ARHGEF26 VGNC VGNC:38082
Macaca mulatta ARHGEF26 VGNC VGNC:69897
Mus musculus ARHGEF26 MGD MGI:1918053
Others ARHGEF26 NCBI