HERC4 - HECT and RLD domain containing E3 ubiquitin protein ligase 4 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26091

About HERC4

Cytogenetic location: 10q21.3 Genomic coordinates (GRCh38): 10:67,921,905-68,075,283 (from NCBI)

This gene has 15 transcripts (splice variants), 201 orthologues and 24 paralogues. Ubiquitous expression in lymph node (RPKM 8.1), adrenal (RPKM 7.4) and 25 other tissues.

Summary

HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

HERC4 Products (5)

mRNA Protein Name
NM_001278185.2 NP_001265114.1 probable E3 ubiquitin-protein ligase HERC4 isoform c
NM_001278186.2 NP_001265115.1 probable E3 ubiquitin-protein ligase HERC4 isoform d
NM_001278187.2 NP_001265116.1 probable E3 ubiquitin-protein ligase HERC4 isoform e
NM_015601.4 NP_056416.2 probable E3 ubiquitin-protein ligase HERC4 isoform b
NM_022079.3 NP_071362.1 probable E3 ubiquitin-protein ligase HERC4 isoform a

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
31010679 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HERC4 Protein Structure

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (3 - 49)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (52 - 99)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (102 - 152)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (157 - 205)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (208 - 257)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (260 - 308)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (313 - 343)

HECT

HECT: HECT-domain (ubiquitin-transferase) (760 - 1056)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1057 a.a.
Protein Preferred Names Protein Names

probable E3 ubiquitin-protein ligase HERC4

  • HECT domain and RCC1-like domain-containing protein 4

Related Diseases

Diseases Alias
Osteonecrosis Of The Jaw
Balantidiasis

  • Balantidiosis

  • Human Balantidiasis

  • B Coli Infection

  • Balantidium Coli Infection

  • Large-Intestinal Infection With Balantidium Coli

  • Ciliary Dysentery
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162563 AK59 Degrader 99.03% Unkown
HY-RS06129 HERC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22551 Herc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29071 Herc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HERC4 VGNC VGNC:51899
Felis catus HERC4 VGNC VGNC:107057
Rattus norvegicus HERC4 RGD RGD:1310971
Bos taurus HERC4 VGNC VGNC:55988
Mus musculus HERC4 MGD MGI:1914595
Macaca mulatta HERC4 VGNC VGNC:106056