Map3k12 - mitogen-activated protein kinase kinase kinase 12 Gene

Mus musculus

Also known as DLK; MUK; Zpk

Gene ID: 26404 | Gene type: protein coding

About Map3k12

Summary

Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in JNK cascade; positive regulation of JUN kinase activity; and protein phosphorylation. Acts upstream of or within negative regulation of motor neuron apoptotic process. Located in cytosol; growth cone; and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human MAP3K12 (mitogen-activated protein kinase kinase kinase 12). [provided by Alliance of Genome Resources, Apr 2022]

Map3k12 Products(5)

mRNA	Protein	Name
NM_001163643.2	NP_001157115.1	mitogen-activated protein kinase kinase kinase 12
NM_001358844.2	NP_001345773.1	mitogen-activated protein kinase kinase kinase 12
NM_001411860.1	NP_001398789.1	mitogen-activated protein kinase kinase kinase 12
NM_001411861.1	NP_001398790.1	mitogen-activated protein kinase kinase kinase 12
NM_009582.5	NP_033608.3	mitogen-activated protein kinase kinase kinase 12

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	8663324	MGI
enables protein serine/threonine kinase activator activity	IMP IMP: Inferred from mutant phenotype	27511108	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	7983011	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	27511108	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IMP IMP: Inferred from mutant phenotype	27511108	MGI
acts upstream of or within negative regulation of motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	25100604	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	7983011	MGI
involved in peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	27511108	MGI
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	7983011	MGI
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	27511108	MGI
involved in positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	27511108	MGI
involved in post-translational protein modification	IDA IDA: Inferred from direct assay	8663324	MGI
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	7983011	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	18031680	MGI
located in cytosol	IDA IDA: Inferred from direct assay	8663324	MGI
located in growth cone	IDA IDA: Inferred from direct assay	18031680	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	8663324	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 12

MAPK-upstream kinase	dual leucine zipper bearing kinase
leucine-zipper protein kinase	mixed lineage kinase
zipper (leucine) protein kinase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114331	DLK-IN-1	Inhibitor	98.27%	Unkown
HY-170484	KAI-11101	Inhibitor	/	Unkown
HY-RS08049	MAP3K12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map3k12	NCBI	NCBI:7786

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