Map3k12 - mitogen-activated protein kinase kinase kinase 12 Gene

Also Known as DLK; MUK; Zpk

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26404

Summary

Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in JNK cascade; positive regulation of JUN kinase activity; and protein phosphorylation. Acts upstream of or within negative regulation of motor neuron apoptotic process. Located in cytosol; growth cone; and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human MAP3K12 (mitogen-activated protein kinase kinase kinase 12). [provided by Alliance of Genome Resources, Apr 2022]

Map3k12 Products (5)

mRNA Protein Name
NM_001163643.2 NP_001157115.1 mitogen-activated protein kinase kinase kinase 12
NM_001358844.2 NP_001345773.1 mitogen-activated protein kinase kinase kinase 12
NM_001411860.1 NP_001398789.1 mitogen-activated protein kinase kinase kinase 12
NM_001411861.1 NP_001398790.1 mitogen-activated protein kinase kinase kinase 12
NM_009582.5 NP_033608.3 mitogen-activated protein kinase kinase kinase 12

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
8663324 MGI
enables protein serine/threonine kinase activator activity IMP
IMP: Inferred from mutant phenotype
27511108 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
7983011 MGI
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
27511108 MGI
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IMP
IMP: Inferred from mutant phenotype
27511108 MGI
acts upstream of or within negative regulation of motor neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
25100604 MGI
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
7983011 MGI
involved in peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
27511108 MGI
involved in peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
7983011 MGI
involved in positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
27511108 MGI
involved in positive regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
27511108 MGI
involved in post-translational protein modification IDA
IDA: Inferred from direct assay
8663324 MGI
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
7983011 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
18031680 MGI
located in cytosol IDA
IDA: Inferred from direct assay
8663324 MGI
located in growth cone IDA
IDA: Inferred from direct assay
18031680 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
8663324 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 12

  • MAPK-upstream kinase

  • dual leucine zipper bearing kinase

  • leucine-zipper protein kinase

  • mixed lineage kinase

  • zipper (leucine) protein kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114331 DLK-IN-1 Inhibitor 98.27% Unkown
HY-170484 KAI-11101 Inhibitor / Unkown
HY-RS08049 MAP3K12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map3k12 NCBI NCBI:7786