2. Gene
  3. MAP3K12 - mitogen-activated protein kinase kinase kinase 12 Gene

MAP3K12 - mitogen-activated protein kinase kinase kinase 12 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DLK; MUK; ZPK; ZPKP1; MEKK12; HP09298

Gene ID: 7786 | Gene type: protein coding

About MAP3K12

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,479,669-53,501,539 (from NCBI)

This gene has 11 transcripts (splice variants), 253 orthologues and 23 paralogues. Ubiquitous expression in urinary bladder (RPKM 14.0), brain (RPKM 12.1) and 25 other tissues.

Summary

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]

MAP3K12 Products(2)

mRNA Protein Name
NM_001193511.2 NP_001180440.1 mitogen-activated protein kinase kinase kinase 12 isoform 1
NM_006301.4 NP_006292.3 mitogen-activated protein kinase kinase kinase 12 isoform 2

MAP3K12 Protein Structure

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (130 - 363)

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  • 859 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 12

MAPK-upstream kinase

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 34

DEE34

Epileptic Encephalopathy, Early Infantile, 34

Eiee34

Developmental And Epileptic Encephalopathy, 34

Early Infantile Epileptic Encephalopathy 34
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114331 DLK-IN-1 Inhibitor 99.41% Unkown
HY-RS08049 MAP3K12 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MAP3K12 VGNC VGNC:68157
Canis familiaris MAP3K12 VGNC VGNC:42968
Macaca mulatta MAP3K12 VGNC VGNC:74493
Bos taurus MAP3K12 VGNC VGNC:31190
Mus musculus MAP3K12 MGD MGI:1346881
Rattus norvegicus MAP3K12 RGD RGD:3988
Others MAP3K12 NCBI