Pla2g10 - phospholipase A2, group X Gene

Mus musculus

Also known as PLA2GX; sPLA2-X; GX sPLA2

Gene ID: 26565 | Gene type: protein coding

About Pla2g10

Summary

This gene encodes a member of the Phospholipase A2 family of lipolytic Enzymes that hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. The encoded protein undergoes proteolytic processing to generate a calcium-dependent enzyme that plays pivotal roles in the liberation of arachidonic acid from membrane Phospholipids leading to the production of various inflammatory lipid mediators, such as prostaglandins. In response to myocardial ischemia/reperfusion, mice lacking the encoded protein display a reduction in myocardial infarct size partly through the suppression of neutorphil cytotoxic activities. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2015]

Pla2g10 Products(2)

mRNA	Protein	Name
NM_001291009.2	NP_001277938.1	group 10 secretory phospholipase A2 isoform 2 preproprotein
NM_011987.4	NP_036117.1	group 10 secretory phospholipase A2 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent phospholipase A2 activity	IDA IDA: Inferred from direct assay	12359733	MGI
enables phospholipase activity	IMP IMP: Inferred from mutant phenotype	20844270	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	20844270	MGI
acts upstream of or within erythrocyte maturation	IMP IMP: Inferred from mutant phenotype	26828067	MGI
acts upstream of or within fertilization	IMP IMP: Inferred from mutant phenotype	26828067	MGI
involved in hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	21266583	MGI
involved in intestinal stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	27292189	MGI
acts upstream of or within macrophage activation	IDA IDA: Inferred from direct assay	26828067	MGI
involved in negative regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	20844270	MGI
involved in negative regulation of cholesterol efflux	IDA IDA: Inferred from direct assay	20844270	MGI
acts upstream of or within negative regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	26828067	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	26828067	MGI
involved in phosphatidic acid metabolic process	IDA IDA: Inferred from direct assay	12359733	MGI
involved in phosphatidylcholine metabolic process	IDA IDA: Inferred from direct assay	12359733	MGI
involved in phosphatidylethanolamine metabolic process	IDA IDA: Inferred from direct assay	12359733	MGI
involved in phosphatidylethanolamine metabolic process	IMP IMP: Inferred from mutant phenotype	21266583	MGI
involved in phosphatidylglycerol metabolic process	IDA IDA: Inferred from direct assay	12359733	MGI
involved in phosphatidylserine metabolic process	IDA IDA: Inferred from direct assay	12359733	MGI
acts upstream of or within phospholipid metabolic process	IMP IMP: Inferred from mutant phenotype	26828067	MGI
involved in positive regulation of acrosome reaction	IMP IMP: Inferred from mutant phenotype	20424324	MGI
involved in positive regulation of arachidonate secretion	IDA IDA: Inferred from direct assay	20844270	MGI
acts upstream of or within production of molecular mediator involved in inflammatory response	IDA IDA: Inferred from direct assay	26828067	MGI
acts upstream of or within production of molecular mediator involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	26828067	MGI
involved in prostaglandin biosynthetic process	IDA IDA: Inferred from direct assay	27292189	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	20424324	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

group 10 secretory phospholipase A2

group X secretory phospholipase A2

phosphatidylcholine 2-acylhydrolase 10

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10616	PLA2G10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pla2g10	NCBI	NCBI:8399

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