Kcnc2 - potassium voltage gated channel, Shaw-related subfamily, member 2 Gene

Mus musculus

Also known as Kv3.2; KShIIIA; B230117I07

Gene ID: 268345 | Gene type: protein coding

About Kcnc2

Summary

Enables transmembrane transporter binding activity. Acts upstream of or within action potential. Located in several cellular components, including neuronal cell body membrane; perikaryon; and synaptic membrane. Is expressed in eye; genitourinary system; gut; heart; and nervous system. Orthologous to human KCNC2 (potassium voltage-gated channel subfamily C member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnc2 Products(5)

mRNA	Protein	Name
NM_001025581.1	NP_001020752.1	potassium voltage-gated channel subfamily C member 2 isoform 2
NM_001359752.1	NP_001346681.1	potassium voltage-gated channel subfamily C member 2 isoform 1
NM_001359753.1	NP_001346682.1	potassium voltage-gated channel subfamily C member 2 isoform 1
NM_001379643.1	NP_001366572.1	potassium voltage-gated channel subfamily C member 2 isoform 1
NM_001379644.1	NP_001366573.1	potassium voltage-gated channel subfamily C member 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10531438	MGI
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	12000114	MGI
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	10561420	MGI
enables voltage-gated potassium channel activity	IMP IMP: Inferred from mutant phenotype	10903572	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within action potential	IMP IMP: Inferred from mutant phenotype	17761775	MGI
involved in membrane hyperpolarization	IMP IMP: Inferred from mutant phenotype	17761775	MGI
involved in potassium ion transport	IDA IDA: Inferred from direct assay	10561420	MGI
involved in potassium ion transport	IMP IMP: Inferred from mutant phenotype	11124984	MGI
involved in regulation of action potential firing rate	IMP IMP: Inferred from mutant phenotype	10561420	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	10903572	MGI
located in cell body	IDA IDA: Inferred from direct assay	15317859	MGI
located in dendrite	IDA IDA: Inferred from direct assay	10531438	MGI
located in membrane	IDA IDA: Inferred from direct assay	12000114	MGI
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	10531438	MGI
located in perikaryon	IDA IDA: Inferred from direct assay	10531438	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15317859	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	10531438	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	10531438	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily C member 2

shaw-like potassium channel

voltage-gated potassium channel Kv3.2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07109	KCNC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnc2	NCBI	NCBI:3747

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