2. Gene
  3. Macroh2a1 - macroH2A.1 histone Gene

Macroh2a1 - macroH2A.1 histone Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as H2afy; mH2a1; H2AF12M

Gene ID: 26914 | Gene type: protein coding

About Macroh2a1

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]

Macroh2a1 Products(4)

mRNA Protein Name
NM_001159513.1 NP_001152985.1 core histone macro-H2A.1 isoform 2
NM_001159514.1 NP_001152986.1 core histone macro-H2A.1 isoform 3
NM_001159515.1 NP_001152987.1 core histone macro-H2A.1 isoform 4
NM_012015.2 NP_036145.1 core histone macro-H2A.1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ADP-D-ribose binding IDA
IDA: Inferred from direct assay
28991266 MGI
enables ADP-D-ribose modification-dependent protein binding IDA
IDA: Inferred from direct assay
28991266 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
12082075 MGI
enables nucleosomal DNA binding IDA
IDA: Inferred from direct assay
18936163 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
18936163 MGI
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of response to oxidative stress IMP
IMP: Inferred from mutant phenotype
23022728 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
25312643 MGI
involved in negative regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
IMP: Inferred from mutant phenotype
24071584 MGI
involved in positive regulation of response to oxidative stress IMP
IMP: Inferred from mutant phenotype
23022728 MGI
involved in regulation of NAD metabolic process IDA
IDA: Inferred from direct assay
28991266 MGI
involved in regulation of oxidative phosphorylation IDA
IDA: Inferred from direct assay
28991266 MGI
involved in regulation of response to oxidative stress IMP
IMP: Inferred from mutant phenotype
23022728 MGI
Cellular Component GO Annotation Evidence Reference Source
located in condensed chromosome IDA
IDA: Inferred from direct assay
12082075 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
28991266 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12419249 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

core histone macro-H2A.1

H2A histone family, member Y

H2A.y

H2A/y

MACROH2A1.2

histone macroH2A1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07947 MACROH2A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Macroh2a1 NCBI NCBI:9555