Macroh2a1 - macroH2A.1 histone Gene

Also Known as H2afy; mH2a1; H2AF12M

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26914

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]

Macroh2a1 Products (4)

mRNA Protein Name
NM_001159513.1 NP_001152985.1 core histone macro-H2A.1 isoform 2
NM_001159514.1 NP_001152986.1 core histone macro-H2A.1 isoform 3
NM_001159515.1 NP_001152987.1 core histone macro-H2A.1 isoform 4
NM_012015.2 NP_036145.1 core histone macro-H2A.1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ADP-D-ribose binding IDA
IDA: Inferred from direct assay
28991266 MGI
enables ADP-D-ribose modification-dependent protein binding IDA
IDA: Inferred from direct assay
28991266 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
12082075 MGI
enables nucleosomal DNA binding IDA
IDA: Inferred from direct assay
18936163 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
18936163 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of response to oxidative stress IMP
IMP: Inferred from mutant phenotype
23022728 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
25312643 MGI
involved in negative regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
IMP: Inferred from mutant phenotype
24071584 MGI
involved in positive regulation of response to oxidative stress IMP
IMP: Inferred from mutant phenotype
23022728 MGI
involved in regulation of NAD metabolic process IDA
IDA: Inferred from direct assay
28991266 MGI
involved in regulation of oxidative phosphorylation IDA
IDA: Inferred from direct assay
28991266 MGI
involved in regulation of response to oxidative stress IMP
IMP: Inferred from mutant phenotype
23022728 MGI
Cellular Component GO Annotation Evidence References Source
located in condensed chromosome IDA
IDA: Inferred from direct assay
12082075 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
28991266 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12419249 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

core histone macro-H2A.1

  • H2A histone family, member Y

  • H2A.y

  • H2A/y

  • MACROH2A1.2

  • histone macroH2A1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07947 MACROH2A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Macroh2a1 NCBI NCBI:9555