Foxl2 - forkhead box L2 Gene

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and Estrogen receptor binding activity. Acts upstream of or within several processes, including positive regulation of gonadotropin secretion; regulation of transcription by RNA polymerase II; and reproductive structure development. Located in nucleus. Is expressed in several structures, including adenohypophysis; branchial arch; eye; future pituitary; and genitourinary system. Used to study blepharophimosis, ptosis, and epicanthus inversus syndrome. Human ortholog(s) of this gene implicated in blepharophimosis, ptosis, and epicanthus inversus syndrome and primary ovarian insufficiency 3. Orthologous to human FOXL2 (forkhead box L2). [provided by Alliance of Genome Resources, Apr 2022]