Lhfpl4 - lipoma HMGIC fusion partner-like protein 4 Gene

Mus musculus

Also known as mKIAA4027; B230384L07; 1190004M23Rik

Gene ID: 269788 | Gene type: protein coding

About Lhfpl4

Summary

Enables GABA Receptor binding activity. Involved in gamma-aminobutyric acid receptor clustering and regulation of inhibitory synapse assembly. Located in inhibitory synapse and postsynaptic membrane. Is expressed in brain; heart; intestine; lung; and reproductive system. Orthologous to human LHFPL4 (LHFPL tetraspan subfamily member 4). [provided by Alliance of Genome Resources, Apr 2022]

Lhfpl4 Products(1)

mRNA	Protein	Name
NM_177763.3	NP_808431.2	LHFPL tetraspan subfamily member 4 protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GABA receptor binding	IDA IDA: Inferred from direct assay	28978485	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	28978485	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in gamma-aminobutyric acid receptor clustering	IMP IMP: Inferred from mutant phenotype	28279354	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	28279354	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	28279354	MGI
involved in regulation of inhibitory synapse assembly	IMP IMP: Inferred from mutant phenotype	29742426	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	28279354	MGI
is active in GABA-ergic synapse	IEP IEP: Inferred from expression pattern	28279354	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	28279354	MGI
located in inhibitory synapse	IDA IDA: Inferred from direct assay	29742426	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	28978485	MGI
located in postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	29742426	MGI
is active in postsynaptic specialization	IDA IDA: Inferred from direct assay	28279354	MGI
is active in postsynaptic specialization	IEP IEP: Inferred from expression pattern	28279354	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

LHFPL tetraspan subfamily member 4 protein

GABAA receptor regulatory Lhfpl4

lipoma HMGIC fusion partner-like 4 protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07627	LHFPL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07628	LHFPL4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lhfpl4	NCBI	NCBI:375323

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