MTBP - MDM2 binding protein Gene

Also Known as MDM2BP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27085

About MTBP

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:120,445,419-120,523,636 (from NCBI)

This gene has 8 transcripts (splice variants) and 198 orthologues. Broad expression in testis (RPKM 2.1), lymph node (RPKM 1.4) and 24 other tissues.

Summary

This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]

MTBP Products (1)

mRNA Protein Name
NM_022045.5 NP_071328.2 mdm2-binding protein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within protein localization to kinetochore IMP
IMP: Inferred from mutant phenotype
21274008 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
21274008 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
21274008 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTBP Protein Structure

MTBP_N

MTBP_N: MDM2-binding (1 - 276)

MTBP_mid

MTBP_mid: MDM2-binding (294 - 632)

MTBP_C

MTBP_C: MDM2-binding (636 - 894)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 904 a.a.
Protein Preferred Names Protein Names

mdm2-binding protein

  • MDM2 (mouse double minute 2)-binding protein, 104kD

Related Diseases

Diseases Alias
Van Esch-O'Driscoll Syndrome

  • X-Linked Intellectual Disability, Van Esch Type

  • VEODS

  • Mrxsveod

  • Mental Retardation, X-Linked, Syndromic, Van Esch-O'Driscoll Type

  • X-Linked Syndromic Mental Retardation Van Esch-O'Driscoll Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08753 MTBP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MTBP RGD RGD:1565672
Felis catus MTBP VGNC VGNC:68336
Bos taurus MTBP VGNC VGNC:31716
Canis familiaris MTBP VGNC VGNC:43458
Macaca mulatta MTBP VGNC VGNC:74944
Mus musculus MTBP MGD MGI:2146005
Others MTBP NCBI