Vps13a - vacuolar protein sorting 13A Gene

Mus musculus

Also known as Chac; Chorein; mKIAA0986; 4930425F11; 9930023P20; 4930516E05Rik; 4930543C13Rik; D330038K10Rik

Gene ID: 271564 | Gene type: protein coding

About Vps13a

Summary

Acts upstream of or within several processes, including flagellated sperm motility; social behavior; and sperm mitochondrion organization. Located in Golgi apparatus; neuronal dense core vesicle lumen; and sperm midpiece. Is expressed in central nervous system; retina; and thymus primordium. Used to study choreaacanthocytosis. Human ortholog(s) of this gene implicated in choreaacanthocytosis and choreatic disease. Orthologous to human VPS13A (vacuolar protein sorting 13 homolog A). [provided by Alliance of Genome Resources, Apr 2022]

Vps13a Products(1)

mRNA	Protein	Name
NM_173028.4	NP_766616.2	intermembrane lipid transfer protein VPS13A

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	37714309	MGI
acts upstream of or within autophagy	IGI IGI: Inferred from genetic interaction	33941276	MGI
acts upstream of or within autophagy	IMP IMP: Inferred from mutant phenotype	33941276	MGI
acts upstream of or within brain-derived neurotrophic factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	37714309	MGI
acts upstream of or within cell morphogenesis	IGI IGI: Inferred from genetic interaction	33941276	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	33941276	MGI
acts upstream of or within cellular response to osmotic stress	IMP IMP: Inferred from mutant phenotype	26921443	MGI
acts upstream of or within chemokine production	IMP IMP: Inferred from mutant phenotype	37714309	MGI
acts upstream of or within erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	33941276	MGI
acts upstream of or within exploration behavior	IMP IMP: Inferred from mutant phenotype	26921443	MGI
acts upstream of or within flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	29928881	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	37714309	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	15686477	MGI
acts upstream of or within long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	37714309	MGI
acts upstream of or within microglia differentiation	IMP IMP: Inferred from mutant phenotype	37714309	MGI
acts upstream of or within motor behavior	IMP IMP: Inferred from mutant phenotype	26921443	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	26921443	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	15686477	MGI
acts upstream of or within neuroinflammatory response	IGI IGI: Inferred from genetic interaction	33941276	MGI
acts upstream of or within neuroinflammatory response	IMP IMP: Inferred from mutant phenotype	33941276	MGI
acts upstream of or within neuromuscular process	IMP IMP: Inferred from mutant phenotype	26921443	MGI
acts upstream of or within neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	26921443	MGI
acts upstream of or within neuron projection arborization	IMP IMP: Inferred from mutant phenotype	37714309	MGI
acts upstream of or within protein metabolic process	IMP IMP: Inferred from mutant phenotype	33941276	MGI
acts upstream of or within protein secretion	IMP IMP: Inferred from mutant phenotype	37714309	MGI
acts upstream of or within regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	37714309	MGI
acts upstream of or within response to environmental enrichment	IMP IMP: Inferred from mutant phenotype	26921443	MGI
acts upstream of or within social behavior	IMP IMP: Inferred from mutant phenotype	15686477	MGI
acts upstream of or within sperm mitochondrion organization	IMP IMP: Inferred from mutant phenotype	29928881	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	22366033	MGI
located in dense core granule	IDA IDA: Inferred from direct assay	22366033	MGI
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	34884823	MGI
is active in mitochondrion	IDA IDA: Inferred from direct assay	34884823	MGI
is active in neuron projection	IDA IDA: Inferred from direct assay	34884823	MGI
is active in neuronal cell body	IDA IDA: Inferred from direct assay	34884823	MGI
located in neuronal dense core vesicle lumen	IDA IDA: Inferred from direct assay	22366033	MGI
located in sperm midpiece	IDA IDA: Inferred from direct assay	29928881	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

intermembrane lipid transfer protein VPS13A

vacuolar protein sorting-associated protein 13A

chorea-acanthocytosis protein homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15672	VPS13A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vps13a	NCBI	NCBI:23230

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