Vps13a - vacuolar protein sorting 13A Gene

Also Known as Chac; Chorein; mKIAA0986; 4930425F11; 9930023P20; 4930516E05Rik; 4930543C13Rik; D330038K10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 271564

Summary

Acts upstream of or within several processes, including flagellated sperm motility; social behavior; and sperm mitochondrion organization. Located in Golgi apparatus; neuronal dense core vesicle lumen; and sperm midpiece. Is expressed in central nervous system; retina; and thymus primordium. Used to study choreaacanthocytosis. Human ortholog(s) of this gene implicated in choreaacanthocytosis and choreatic disease. Orthologous to human VPS13A (vacuolar protein sorting 13 homolog A). [provided by Alliance of Genome Resources, Apr 2022]

Vps13a Products (1)

mRNA Protein Name
NM_173028.4 NP_766616.2 intermembrane lipid transfer protein VPS13A

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
37714309 MGI
acts upstream of or within autophagy IGI
IGI: Inferred from genetic interaction
33941276 MGI
acts upstream of or within autophagy IMP
IMP: Inferred from mutant phenotype
33941276 MGI
acts upstream of or within brain-derived neurotrophic factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
37714309 MGI
acts upstream of or within cell morphogenesis IGI
IGI: Inferred from genetic interaction
33941276 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
33941276 MGI
acts upstream of or within cellular response to osmotic stress IMP
IMP: Inferred from mutant phenotype
26921443 MGI
acts upstream of or within chemokine production IMP
IMP: Inferred from mutant phenotype
37714309 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
33941276 MGI
acts upstream of or within exploration behavior IMP
IMP: Inferred from mutant phenotype
26921443 MGI
acts upstream of or within flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
29928881 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
37714309 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
15686477 MGI
acts upstream of or within long-term synaptic depression IMP
IMP: Inferred from mutant phenotype
37714309 MGI
acts upstream of or within microglia differentiation IMP
IMP: Inferred from mutant phenotype
37714309 MGI
acts upstream of or within motor behavior IMP
IMP: Inferred from mutant phenotype
26921443 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
26921443 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
15686477 MGI
acts upstream of or within neuroinflammatory response IGI
IGI: Inferred from genetic interaction
33941276 MGI
acts upstream of or within neuroinflammatory response IMP
IMP: Inferred from mutant phenotype
33941276 MGI
acts upstream of or within neuromuscular process IMP
IMP: Inferred from mutant phenotype
26921443 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
26921443 MGI
acts upstream of or within neuron projection arborization IMP
IMP: Inferred from mutant phenotype
37714309 MGI
acts upstream of or within protein metabolic process IMP
IMP: Inferred from mutant phenotype
33941276 MGI
acts upstream of or within protein secretion IMP
IMP: Inferred from mutant phenotype
37714309 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
37714309 MGI
acts upstream of or within response to environmental enrichment IMP
IMP: Inferred from mutant phenotype
26921443 MGI
acts upstream of or within social behavior IMP
IMP: Inferred from mutant phenotype
15686477 MGI
acts upstream of or within sperm mitochondrion organization IMP
IMP: Inferred from mutant phenotype
29928881 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
22366033 MGI
located in dense core granule IDA
IDA: Inferred from direct assay
22366033 MGI
is active in endoplasmic reticulum IDA
IDA: Inferred from direct assay
34884823 MGI
is active in mitochondrion IDA
IDA: Inferred from direct assay
34884823 MGI
is active in neuron projection IDA
IDA: Inferred from direct assay
34884823 MGI
is active in neuronal cell body IDA
IDA: Inferred from direct assay
34884823 MGI
located in neuronal dense core vesicle lumen IDA
IDA: Inferred from direct assay
22366033 MGI
located in sperm midpiece IDA
IDA: Inferred from direct assay
29928881 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intermembrane lipid transfer protein VPS13A

vacuolar protein sorting-associated protein 13A

  • chorea-acanthocytosis protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15672 VPS13A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vps13a NCBI NCBI:23230