NMRK2 - nicotinamide riboside kinase 2 Gene

Also Known as MIBP; NRK2; ITGB1BP3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27231

About NMRK2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,933,069-3,942,416 (from NCBI)

This gene has 5 transcripts (splice variants), 264 orthologues and 3 paralogues. Restricted expression toward heart (RPKM 167.4).

Summary

Enables ribosylnicotinamide kinase activity and ribosylnicotinate kinase activity. Predicted to be involved in NAD metabolic process. Predicted to act upstream of or within negative regulation of myoblast differentiation. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

NMRK2 Products (5)

mRNA Protein Name
NM_001289117.2 NP_001276046.1 nicotinamide riboside kinase 2 isoform 1
NM_001375467.2 NP_001362396.1 nicotinamide riboside kinase 2 isoform 3
NM_001375468.2 NP_001362397.1 nicotinamide riboside kinase 2 isoform 4
NM_001375469.2 NP_001362398.1 nicotinamide riboside kinase 2 isoform 5
NM_170678.3 NP_733778.1 nicotinamide riboside kinase 2 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12809483 GOA
enables ribosylnicotinamide kinase activity EXP
EXP: Inferred from Experiment
15137942 GOA
enables ribosylnicotinate kinase activity EXP
EXP: Inferred from Experiment
15137942 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NMRK2 Protein Structure

AAA_18

AAA_18: AAA domain (5 - 143)

  • 0
  • 100
  • 200
  • 230 a.a.
Protein Preferred Names Protein Names

nicotinamide riboside kinase 2

  • NRK 2

Related Diseases

Diseases Alias
Muscular Dystrophy, Congenital, Due To Integrin Alpha-7 Deficiency

  • Congenital Muscular Dystrophy Due To Integrin Alpha-7 Deficiency

  • Muscular Dystrophy, Congenital, Due To Itga7 Deficiency

  • Congenital Muscular Dystrophy With Integrin Alpha-7 Deficiency

  • Congenital Muscular Dystrophy With Itga7 Deficiency

  • Congenital Myopathy Due To Integrin Alpha-7 Deficiency

  • Myopathy, Congenital, Due To Integrin Alpha-7 Deficiency

  • Muscular Dystrophy Congenital Due To Integrin Alpha-7 Deficiency

  • MDCI

  • Dystrophy, Muscular, Congenital, Due To Integrin Alpha-7 Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09387 NMRK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NMRK2 VGNC VGNC:106842
Mus musculus NMRK2 MGD MGI:1916814
Rattus norvegicus NMRK2 RGD RGD:6486791
Macaca mulatta NMRK2 VGNC VGNC:75203
Others NMRK2 NCBI