Arntl2 - aryl hydrocarbon receptor nuclear translocator-like 2 Gene

Also Known as CLIF; MOP9; BMAL2; bHLHe6; 4632430A05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 272322

Summary

This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (Per, Arnt, Sim) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian Clock protein, the structurally related Mop4, and hypoxia-inducible factors, such as Hif1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]

Arntl2 Products (4)

mRNA Protein Name
NM_001289679.1 NP_001276608.1 aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 2
NM_001289680.1 NP_001276609.1 aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 3
NM_001289681.1 NP_001276610.1 aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 4
NM_172309.2 NP_758513.1 aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables E-box binding IDA
IDA: Inferred from direct assay
19605937 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19605937 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19605937 MGI
involved in positive regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
19605937 MGI
Cellular Component GO Annotation Evidence References Source
part of CLOCK-BMAL transcription complex IPI
IPI: Inferred from physical interaction
25961797 MGI
located in nucleus IDA
IDA: Inferred from direct assay
25961797 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aryl hydrocarbon receptor nuclear translocator-like protein 2

  • brain and muscle ARNT-like 2

  • brain-muscle-ARNT-like protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01530 BMAL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown