SIT1 - signaling threshold regulating transmembrane adaptor 1 Gene

Homo sapiens

Also known as SIT; SIT-R

Gene ID: 27240 | Gene type: protein coding

About SIT1

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,649,295-35,650,931 (from NCBI)

This gene has 3 transcripts (splice variants) and 89 orthologues. Biased expression in lymph node (RPKM 22.9), appendix (RPKM 10.2) and 8 other tissues.

Summary

Enables kinase binding activity. Involved in regulation of T cell activation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SIT1 Products(1)

mRNA	Protein	Name
NM_014450.3	NP_055265.1	signaling threshold-regulating transmembrane adapter 1 precursor

SIT1 Protein Structure

SIT

0
100
196 a.a.

Protein Preferred Names

Protein Names

signaling threshold-regulating transmembrane adapter 1

SHP-2 interacting transmembrane adaptor protein

Related Diseases

Diseases

Alias

Hartnup Disorder

Hartnup Disease	HND
Neutral 1 Amino Acid Transport Defect	Neutral Amino Acid Transport Defect
Deficiency Of Tryptophan Oxygenase	Hartnup'S Disease
Aminoaciduria, Hartnup Type	Disorder Of Neutral Amino Acid Transport

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12956	SIT1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SIT1	MGD	MGI:1889342
Bos taurus	SIT1	VGNC	VGNC:34637
Canis familiaris	SIT1	VGNC	VGNC:46189
Rattus norvegicus	SIT1	RGD	RGD:1559919