SIT1 - signaling threshold regulating transmembrane adaptor 1 Gene

Also Known as SIT; SIT-R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27240

About SIT1

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,649,295-35,650,931 (from NCBI)

This gene has 3 transcripts (splice variants) and 89 orthologues. Biased expression in lymph node (RPKM 22.9), appendix (RPKM 10.2) and 8 other tissues.

Summary

Enables kinase binding activity. Involved in regulation of T cell activation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SIT1 Products (1)

mRNA Protein Name
NM_014450.3 NP_055265.1 signaling threshold-regulating transmembrane adapter 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kinase binding IPI
IPI: Inferred from physical interaction
10209036 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10209036 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of T cell activation IDA
IDA: Inferred from direct assay
10209036 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
10209036 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIT1 Protein Structure

SIT

SIT: SHP2-interacting transmembrane adaptor protein, SIT (45 - 138)

  • 0
  • 100
  • 196 a.a.
Protein Preferred Names Protein Names

signaling threshold-regulating transmembrane adapter 1

  • SHP-2 interacting transmembrane adaptor protein

Related Diseases

Diseases Alias
Hartnup Disorder

  • Hartnup Disease

  • HND

  • Neutral 1 Amino Acid Transport Defect

  • Neutral Amino Acid Transport Defect

  • Deficiency Of Tryptophan Oxygenase

  • Hartnup'S Disease

  • Aminoaciduria, Hartnup Type

  • Disorder Of Neutral Amino Acid Transport
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13307 SLC6A20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12956 SIT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22324 Sit1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28846 Sit1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SIT1 MGD MGI:1889342
Bos taurus SIT1 VGNC VGNC:34637
Canis familiaris SIT1 VGNC VGNC:46189
Rattus norvegicus SIT1 RGD RGD:1559919
Others SIT1 NCBI