TINAG - tubulointerstitial nephritis antigen Gene

Also Known as TIN-AG

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27283

About TINAG

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:54,307,862-54,390,142 (from NCBI)

This gene has 4 transcripts (splice variants), 285 orthologues and 12 paralogues. Biased expression in kidney (RPKM 36.8), colon (RPKM 4.4) and 2 other tissues.

Summary

This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]

TINAG Products (1)

mRNA Protein Name
NM_014464.4 NP_055279.3 tubulointerstitial nephritis antigen

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cell adhesion IDA
IDA: Inferred from direct assay
8770961 GOA
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
1762287 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TINAG Protein Structure

Somatomedin_B

Somatomedin_B: Somatomedin B domain (60 - 106)

Peptidase_C1

Peptidase_C1: Papain family cysteine protease (236 - 464)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
Protein Preferred Names Protein Names

tubulointerstitial nephritis antigen

Related Diseases

Diseases Alias
Membranous Nephropathy

  • Membranous Glomerulonephritis

  • Glomerulonephritis, Membranous

  • Idiopathic Membranous Nephropathy

  • Idiopathic Membranous Glomerulonephritis

  • MBNP

  • Membranous Nephropathy, Susceptibility To

  • Extramembranous Glomerulonephritis

  • Mgn

  • Membranous Gn

  • Primary Membranous Glomerulonephritis

  • Primary Membranous Nephropathy

  • Nephropathy Membranous
Interstitial Nephritis

  • Nephritis, Interstitial

  • Renal Tubulo-Interstitial Disease

  • Nephritis Interstitial

  • Nephritis, Tubulointerstitial
Tinea Barbae

  • Dermatophytosis Of Beard
Tinea Imbricata

  • Kerion Celsi

  • Trichophyton Infection

  • Tinea Imbricata, Susceptibility To

  • Susceptibility To Tinea Imbricata

  • Tinea Capitis Profunda

  • Trichophytia Profunda Barbae

  • Trichophytia Profunda Capitis

  • Tinea Capitis
Tinea Manuum

  • Tinea Manus

  • Dermatophytosis Of Hand
Tinea Cruris

  • Dermatophytosis Of Groin & Perianal Area

  • Dermatophytosis Of Groin And Perianal Area

  • Dhobie Itch

  • Tinea Of Perianal Region
Tinea Unguium

  • Dermatophytosis Of Nail

  • Onychomycosis Due To Dermatophyte

  • Cellulitis And Abscess

  • Cellulitis And Abscess Of Buttock

  • Cellulitis And Abscess Of Face

  • Cellulitis And Abscess Of Finger

  • Cellulitis And Abscess Of Finger And Toe

  • Cellulitis And Abscess Of Gluteal Region

  • Cellulitis And Abscess Of Trunk

  • Cellulitis And Abscess Of Upper Arm And Forearm

  • Dermatophytic Onychia

  • Dermatophytic Onychomycosis

  • Onychomycosis

  • Ringworm Of Nails

  • Tinea Of Nail
Tinea Corporis

  • Dermatophytosis Of The Body

  • Dermatophytosis Of The Trunk
Tinea Capitis

  • Dermatophytosis Of Scalp

  • Scalp Ringworm

  • Dermatophytosis Of Scalp Or Beard

  • Tinea Capitis Due To Trichophyton Rubrum

  • Trichophyton Rubrum Tinea Capitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14542 TINAG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20116 Tinag Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26620 Tinag Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TINAG VGNC VGNC:35874
Rattus norvegicus TINAG RGD RGD:1359482
Canis familiaris TINAG VGNC VGNC:47379
Mus musculus TINAG MGD MGI:1349477
Felis catus TINAG VGNC VGNC:66195
Macaca mulatta TINAG VGNC VGNC:78382
Others TINAG NCBI