Dguok - deoxyguanosine kinase Gene

Also Known as dGK; dGK1; dGK2; dGK3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27369

Summary

Enables deoxyadenosine kinase activity and deoxyguanosine kinase activity. Acts upstream of or within dGTP metabolic process and protein phosphorylation. Located in cytosol and mitochondrion. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 3; Mitochondrial Metabolism disease; and portal hypertension. Orthologous to human DGUOK (deoxyguanosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Dguok Products (2)

mRNA Protein Name
NM_001162521.2 NP_001155993.1 deoxyguanosine kinase, mitochondrial isoform 2
NM_013764.3 NP_038792.2 deoxyguanosine kinase, mitochondrial isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables deoxyguanosine kinase activity IDA
IDA: Inferred from direct assay
1664183 MGI
enables deoxynucleoside kinase activity IDA
IDA: Inferred from direct assay
6260206 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within dGTP metabolic process IDA
IDA: Inferred from direct assay
1664183 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
10455141 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10455141 MGI
located in cytosol IDA
IDA: Inferred from direct assay
7918681 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
10455141 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

deoxyguanosine kinase, mitochondrial

  • deoxyadenosine kinase, mitochondrial

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03725 DGUOK Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dguok NCBI NCBI:1716