Magel2 - MAGE family member L2 Gene

Also Known as ns7; nM15; NDNL1; Mage-l2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27385

Summary

Predicted to enable ubiquitin-protein transferase activity. Involved in negative regulation of transcription, DNA-templated and regulation of circadian rhythm. Acts upstream of or within positive regulation of actin nucleation. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; egg cylinder; future spinal cord; limb bud; and reproductive system. Used to study Prader-Willi syndrome. Human ortholog(s) of this gene implicated in Schaaf-Yang syndrome. Orthologous to human MAGEL2 (MAGE family member L2). [provided by Alliance of Genome Resources, Apr 2022]

Magel2 Products (1)

mRNA Protein Name
NM_013779.2 NP_038807.4 MAGE-like protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14593116 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
22208286 MGI
acts upstream of or within positive regulation of actin nucleation IGI
IGI: Inferred from genetic interaction
23452853 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
22208286 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22208286 MGI
located in nucleus IDA
IDA: Inferred from direct assay
22208286 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MAGE-like protein 2

  • melanoma antigen, family L, 2

  • melanoma antigen-like gene 2

  • necdin-like 1

  • protein nS7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07980 MAGEL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Magel2 NCBI NCBI:54551