POLM - DNA polymerase mu Gene

Also Known as Tdt-N; Pol Mu

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27434

About POLM

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,072,062-44,082,530 (from NCBI)

This gene has 18 transcripts (splice variants), 185 orthologues and 3 paralogues. Ubiquitous expression in spleen (RPKM 6.9), lymph node (RPKM 5.6) and 25 other tissues.

Summary

Predicted to enable DNA-directed DNA Polymerase activity. Predicted to be involved in double-strand break repair via nonhomologous end joining. Predicted to act upstream of or within B cell differentiation and somatic hypermutation of immunoglobulin genes. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

POLM Products (4)

mRNA	Protein	Name
NM_001284330.2	NP_001271259.1	DNA-directed DNA/RNA polymerase mu isoform 2
NM_001284331.2	NP_001271260.1	DNA-directed DNA/RNA polymerase mu isoform 3
NM_001362683.2	NP_001349612.1	DNA-directed DNA/RNA polymerase mu isoform 4
NM_013284.4	NP_037416.1	DNA-directed DNA/RNA polymerase mu isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22458338	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLM Protein Structure

HHH_8

DNA_pol_lambd_f

DNA_pol_B_palm

DNA_pol_B_thumb

0
100
200
300
400
494 a.a.

Protein Preferred Names	Protein Names
DNA-directed DNA/RNA polymerase mu	Pol iota

POLM Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	POLM	Q9NP87	tax	Human T-cell leukemia virus 1	P14079	Y2H Array	22458338
Cross	POLM	Q9NP87	tax	Human T-cell leukemia virus 1	P14079	Y2H Pooling	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

POLM Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86846	DNA polymerase mu Antibody (YA6539)	WB	Human

Related Diseases

Diseases	Alias
Nemaline Myopathy 3	Nemaline Myopathy 3, Autosomal Dominant Or Recessive Congenital Myopathy With Excess Of Thin Filaments NEM3 Myopathy, Actin, Congenital, With Cores Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments Actin-Accumulation Myopathy Actin Myopathy Actin Accumulation Myopathy Actin Filament Aggregate Myopathy Nemaline Myopathy, Type 3 MPCETM Acta1-Related Nemaline Myopathy Actin Myopathy Congenital With Cores Nemaline Myopathy 3 With Intranuclear Rods Myopathy, Nemaline, Type 3
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Lig4 Syndrome	Dna Ligase Iv Deficiency Ligase 4 Syndrome LIG4S
Lung Adenoma	Adenoma Of Lung Pulmonary Adenoma
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10834	POLM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	POLM	VGNC	VGNC:33128
Mus musculus	POLM	MGD	MGI:1860191
Rattus norvegicus	POLM	RGD	RGD:1308247
Macaca mulatta	POLM	VGNC	VGNC:81742
Felis catus	POLM	VGNC	VGNC:68945
Canis familiaris	POLM	VGNC	VGNC:103698
Others	POLM	NCBI