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GNGT2 - G protein subunit gamma transducin 2 Gene

Also Known as GNG9; HG3I; GNGT8; G-GAMMA-8; G-GAMMA-C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2793

About GNGT2

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:49,206,234-49,210,574 (from NCBI)

This gene has 6 transcripts (splice variants), 170 orthologues and 11 paralogues. Broad expression in spleen (RPKM 5.8), lymph node (RPKM 4.5) and 21 other tissues.

Summary

Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]

GNGT2 Products (4)

mRNA	Protein	Name
NM_001198754.2	NP_001185683.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
NM_001198755.1	NP_001185684.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
NM_001198756.1	NP_001185685.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
NM_031498.2	NP_113686.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	10570481	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of heterotrimeric G-protein complex	IDA IDA: Inferred from direct assay	10570481	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNGT2 Protein Structure

G-gamma

0
69 a.a.

Protein Preferred Names	Protein Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	G protein cone gamma 8 subunit

Related Diseases

Diseases	Alias
Adenosquamous Lung Carcinoma
Night Blindness, Congenital Stationary, Autosomal Dominant 2	Congenital Stationary Night Blindness Autosomal Dominant 2 CSNBAD2 Hemeralopia Night Blindness, Congenital Stationary, Rambusch Type Rambusch Type Congenital Stationary Night Blindness Congenital Stationary Night Blindness Rambusch Type Hemeralopia Congenital Essential Blindness, Night, Stationary, Congenital, Autosomal Dominant, Type 2
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05563	GNGT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GNGT2	VGNC	VGNC:29471
Rattus norvegicus	GNGT2	RGD	RGD:1591007
Mus musculus	GNGT2	MGD	MGI:893584
Felis catus	GNGT2	VGNC	VGNC:99069
Canis familiaris	GNGT2	VGNC	VGNC:41325
Others	GNGT2	NCBI