Cep63 - centrosomal protein 63 Gene
Also Known as ET2; CD20R; D9Mgc41; D9Mgc48e; 4921501M07; AL450317.13gm1
Species: Mus musculus
Gene Type: protein coding
Gene ID: 28135
Summary
This gene encodes a subunit of the centrosome, the main microtubule-organizing center of the cell. The encoded protein associates with another centrosomal protein, CEP152, to regulate mother-centriole-dependent centriole duplication in dividing cells. Disruption of a similar gene in human has been associated with primary microcephaly (MCPH). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Cep63 Products (27)
| mRNA | Protein | Name |
|---|---|---|
| NM_001081122.2 | NP_001074591.1 | centrosomal protein of 63 kDa isoform 1 |
| NM_001301689.2 | NP_001288618.1 | centrosomal protein of 63 kDa isoform 2 |
| NM_001407699.1 | NP_001394628.1 | centrosomal protein of 63 kDa isoform 3 |
| NM_001407700.1 | NP_001394629.1 | centrosomal protein of 63 kDa isoform 4 |
| NM_001407701.1 | NP_001394630.1 | centrosomal protein of 63 kDa isoform 5 |
| NM_001407702.1 | NP_001394631.1 | centrosomal protein of 63 kDa isoform 5 |
| NM_001407703.1 | NP_001394632.1 | centrosomal protein of 63 kDa isoform 6 |
| NM_001407704.1 | NP_001394633.1 | centrosomal protein of 63 kDa isoform 7 |
| NM_001407705.1 | NP_001394634.1 | centrosomal protein of 63 kDa isoform 8 |
| NM_001407706.1 | NP_001394635.1 | centrosomal protein of 63 kDa isoform 9 |
| NM_001407707.1 | NP_001394636.1 | centrosomal protein of 63 kDa isoform 10 |
| NM_001407708.1 | NP_001394637.1 | centrosomal protein of 63 kDa isoform 11 |
| NM_001407709.1 | NP_001394638.1 | centrosomal protein of 63 kDa isoform 12 |
| NM_001407710.1 | NP_001394639.1 | centrosomal protein of 63 kDa isoform 13 |
| NM_001407711.1 | NP_001394640.1 | centrosomal protein of 63 kDa isoform 14 |
| NM_001407712.1 | NP_001394641.1 | centrosomal protein of 63 kDa isoform 14 |
| NM_001407713.1 | NP_001394642.1 | centrosomal protein of 63 kDa isoform 14 |
| NM_001407714.1 | NP_001394643.1 | centrosomal protein of 63 kDa isoform 15 |
| NM_001407715.1 | NP_001394644.1 | centrosomal protein of 63 kDa isoform 15 |
| NM_001407716.1 | NP_001394645.1 | centrosomal protein of 63 kDa isoform 16 |
| NM_001407717.1 | NP_001394646.1 | centrosomal protein of 63 kDa isoform 16 |
| NM_001407718.1 | NP_001394647.1 | centrosomal protein of 63 kDa isoform 17 |
| NM_001407719.1 | NP_001394648.1 | centrosomal protein of 63 kDa isoform 18 |
| NM_001407720.1 | NP_001394649.1 | centrosomal protein of 63 kDa isoform 19 |
| NM_001407721.1 | NP_001394650.1 | centrosomal protein of 63 kDa isoform 20 |
| NM_001407722.1 | NP_001394651.1 | centrosomal protein of 63 kDa isoform 21 |
| NM_001407723.1 | NP_001394652.1 | centrosomal protein of 63 kDa isoform 22 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
24240477 | MGI |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within centriole replication |
IMP
IMP: Inferred from mutant phenotype
|
26158450 | MGI |
| involved in centriole replication |
IMP
IMP: Inferred from mutant phenotype
|
24240477 | MGI |
| acts upstream of or within centrosome duplication |
IMP
IMP: Inferred from mutant phenotype
|
26158450 | MGI |
| acts upstream of intrinsic apoptotic signaling pathway by p53 class mediator |
IGI
IGI: Inferred from genetic interaction
|
26158450 | MGI |
| acts upstream of or within meiotic telomere clustering |
IMP
IMP: Inferred from mutant phenotype
|
26158450 | MGI |
| acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
IGI
IGI: Inferred from genetic interaction
|
26158450 | MGI |
| acts upstream of or within protein localization to centrosome |
IMP
IMP: Inferred from mutant phenotype
|
26158450 | MGI |
| acts upstream of or within reciprocal meiotic recombination |
IMP
IMP: Inferred from mutant phenotype
|
26158450 | MGI |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in centriole |
IDA
IDA: Inferred from direct assay
|
24240477 | MGI |
| located in centrosome |
IDA
IDA: Inferred from direct assay
|
26158450 | MGI |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
centrosomal protein of 63 kDa |
|
Related Agents
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Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS02519 | CEP63 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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