2. Gene
  3. Cep63 - centrosomal protein 63 Gene

Cep63 - centrosomal protein 63 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ET2; CD20R; D9Mgc41; D9Mgc48e; 4921501M07; AL450317.13gm1

Gene ID: 28135 | Gene type: protein coding

About Cep63

Summary

This gene encodes a subunit of the centrosome, the main microtubule-organizing center of the cell. The encoded protein associates with another centrosomal protein, CEP152, to regulate mother-centriole-dependent centriole duplication in dividing cells. Disruption of a similar gene in human has been associated with primary microcephaly (MCPH). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Cep63 Products(27)

mRNA Protein Name
NM_001081122.2 NP_001074591.1 centrosomal protein of 63 kDa isoform 1
NM_001301689.2 NP_001288618.1 centrosomal protein of 63 kDa isoform 2
NM_001407699.1 NP_001394628.1 centrosomal protein of 63 kDa isoform 3
NM_001407700.1 NP_001394629.1 centrosomal protein of 63 kDa isoform 4
NM_001407701.1 NP_001394630.1 centrosomal protein of 63 kDa isoform 5
NM_001407702.1 NP_001394631.1 centrosomal protein of 63 kDa isoform 5
NM_001407703.1 NP_001394632.1 centrosomal protein of 63 kDa isoform 6
NM_001407704.1 NP_001394633.1 centrosomal protein of 63 kDa isoform 7
NM_001407705.1 NP_001394634.1 centrosomal protein of 63 kDa isoform 8
NM_001407706.1 NP_001394635.1 centrosomal protein of 63 kDa isoform 9
NM_001407707.1 NP_001394636.1 centrosomal protein of 63 kDa isoform 10
NM_001407708.1 NP_001394637.1 centrosomal protein of 63 kDa isoform 11
NM_001407709.1 NP_001394638.1 centrosomal protein of 63 kDa isoform 12
NM_001407710.1 NP_001394639.1 centrosomal protein of 63 kDa isoform 13
NM_001407711.1 NP_001394640.1 centrosomal protein of 63 kDa isoform 14
NM_001407712.1 NP_001394641.1 centrosomal protein of 63 kDa isoform 14
NM_001407713.1 NP_001394642.1 centrosomal protein of 63 kDa isoform 14
NM_001407714.1 NP_001394643.1 centrosomal protein of 63 kDa isoform 15
NM_001407715.1 NP_001394644.1 centrosomal protein of 63 kDa isoform 15
NM_001407716.1 NP_001394645.1 centrosomal protein of 63 kDa isoform 16
NM_001407717.1 NP_001394646.1 centrosomal protein of 63 kDa isoform 16
NM_001407718.1 NP_001394647.1 centrosomal protein of 63 kDa isoform 17
NM_001407719.1 NP_001394648.1 centrosomal protein of 63 kDa isoform 18
NM_001407720.1 NP_001394649.1 centrosomal protein of 63 kDa isoform 19
NM_001407721.1 NP_001394650.1 centrosomal protein of 63 kDa isoform 20
NM_001407722.1 NP_001394651.1 centrosomal protein of 63 kDa isoform 21
NM_001407723.1 NP_001394652.1 centrosomal protein of 63 kDa isoform 22
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24240477 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within centriole replication IMP
IMP: Inferred from mutant phenotype
26158450 MGI
involved in centriole replication IMP
IMP: Inferred from mutant phenotype
24240477 MGI
acts upstream of or within centrosome duplication IMP
IMP: Inferred from mutant phenotype
26158450 MGI
acts upstream of intrinsic apoptotic signaling pathway by p53 class mediator IGI
IGI: Inferred from genetic interaction
26158450 MGI
acts upstream of or within meiotic telomere clustering IMP
IMP: Inferred from mutant phenotype
26158450 MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IGI
IGI: Inferred from genetic interaction
26158450 MGI
acts upstream of or within protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
26158450 MGI
acts upstream of or within reciprocal meiotic recombination IMP
IMP: Inferred from mutant phenotype
26158450 MGI
Cellular Component GO Annotation Evidence Reference Source
located in centriole IDA
IDA: Inferred from direct assay
24240477 MGI
located in centrosome IDA
IDA: Inferred from direct assay
26158450 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

centrosomal protein of 63 kDa

centrosome protein Cep63

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02519 CEP63 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cep63 NCBI NCBI:80254