SLC46A3 - solute carrier family 46 member 3 Gene

Also Known as FKSG16

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 283537

About SLC46A3

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:28,700,080-28,718,970 (from NCBI)

This gene has 3 transcripts (splice variants), 231 orthologues and 2 paralogues. Broad expression in small intestine (RPKM 41.0), duodenum (RPKM 24.5) and 21 other tissues.

Summary

The protein encoded by this gene is a member of a transmembrane protein family that transports small molecules across membranes. The encoded protein has been found in lysosomal membranes, where it can transport catabolites from the lysosomes to the cytoplasm. This protein has been shown to be an effective transporter of the cytotoxic drug maytansine, which is used in antibody-based targeting of Cancer cells. [provided by RefSeq, Dec 2016]

SLC46A3 Products (3)

mRNA	Protein	Name
NM_001135919.2	NP_001129391.1	solute carrier family 46 member 3 isoform b precursor
NM_001347960.2	NP_001334889.1	solute carrier family 46 member 3 isoform a precursor
NM_181785.4	NP_861450.1	solute carrier family 46 member 3 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	26631267	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in vacuolar transmembrane transport	IMP IMP: Inferred from mutant phenotype	26631267	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in lysosomal membrane	IMP IMP: Inferred from mutant phenotype	26631267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC46A3 Protein Structure

MFS_1

0
100
200
300
400
461 a.a.

Protein Preferred Names	Protein Names
solute carrier family 46 member 3

Related Diseases

Diseases	Alias
Folate Malabsorption, Hereditary	Hereditary Folate Malabsorption Congenital Defect Of Folate Absorption Congenital Folate Malabsorption Folic Acid Transport Defect HFM

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13262	SLC46A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC46A3	VGNC	VGNC:77781
Bos taurus	SLC46A3	VGNC	VGNC:34886
Canis familiaris	SLC46A3	VGNC	VGNC:46428
Felis catus	SLC46A3	VGNC	VGNC:65381
Rattus norvegicus	SLC46A3	RGD	RGD:1307594
Mus musculus	SLC46A3	MGD	MGI:1918956