PLA2G4D - phospholipase A2 group IVD Gene

Also Known as cPLA2delta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 283748

About PLA2G4D

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:42,067,009-42,094,562 (from NCBI)

This gene has 3 transcripts (splice variants), 140 orthologues and 5 paralogues. Biased expression in skin (RPKM 6.8), prostate (RPKM 6.7) and 2 other tissues.

Summary

The Phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009]

PLA2G4D Products (1)

mRNA Protein Name
NM_178034.4 NP_828848.3 cytosolic phospholipase A2 delta

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent phospholipase A2 activity IDA
IDA: Inferred from direct assay
14709560 GOA
Biological Process GO Annotation Evidence References Source
involved in glycerophospholipid catabolic process IDA
IDA: Inferred from direct assay
14709560 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G4D Protein Structure

C2

C2: C2 domain (24 - 104)

PLA2_B

PLA2_B: Lysophospholipase catalytic domain (323 - 514)

  • 0
  • 200
  • 400
  • 600
  • 818 a.a.
Protein Preferred Names Protein Names

cytosolic phospholipase A2 delta

  • cPLA2-delta

Related Diseases

Diseases Alias
Dyskeratosis Congenita, Autosomal Recessive 2

  • DKCB2

  • Autosomal Recessive Dyskeratosis Congenita 2

  • Dyskeratosis Congenita, Autosomal Recessive, 2

  • Dyskeratosis Congenita, Autosomal Recessive, Type 2
Immunodeficiency 29

  • Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12b Deficiency

  • IMD29

  • Il12b Deficiency

  • Immunodeficiency 29, Mycobacteriosis

  • Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interleukin 12b Deficiency

  • Msmd Due To Complete Il12b Deficiency

  • Msmd Due To Complete Interleukin 12b Deficiency

  • Immunodeficiency, Type 29, Mycobacteriosis
Oliver-Mcfarlane Syndrome

  • Trichomegaly-Retina Pigmentary Degeneration-Dwarfism Syndrome

  • OMCS

  • Long Eyelashes-Intellectual Disability Syndrome

  • Trichomegaly With Mental Retardation, Dwarfism, And Pigmentary Degeneration Of Retina

  • Eyelashes, Long, With Mental Retardation

  • Eyelashes Long Mental Retardation

  • Trichomegaly With Intellectual Disability, Dwarfism And Pigmentary Degeneration

  • Trichomegaly With Intellectual Disability, Dwarfism And Pigmentary Degeneration Of Retina

  • Eyelashes, Long With Intellectual Disability

  • Oliver Mcfarlane Syndrome

  • Congenital Trichomegaly, Pigmentary Retinal Degeneration, And Short Stature

  • Trichomegaly, Retina Pigmentary Degeneration, Dwarfism

  • Trichomegaly Retina Pigmentary Degeneration Dwarfism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10629 PLA2G4D Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PLA2G4D VGNC VGNC:44627
Bos taurus PLA2G4D VGNC VGNC:32961
Felis catus PLA2G4D VGNC VGNC:64200
Mus musculus PLA2G4D MGD MGI:1925640
Macaca mulatta PLA2G4D VGNC VGNC:76136
Rattus norvegicus PLA2G4D RGD RGD:1593372
Others PLA2G4D NCBI