NWD1 - NACHT and WD repeat domain containing 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 284434

About NWD1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,719,847-16,817,963 (from NCBI)

This gene has 12 transcripts (splice variants), 111 orthologues and 26 paralogues. Biased expression in prostate (RPKM 3.7), brain (RPKM 1.6) and 6 other tissues.

Summary

The protein encoded by this gene is thought to be a cytosolic protein and predicted to contain a NACHT domain and multiple WD40 repeats. Increased expression of this gene was observed in some prostate Cancer cell lines. Knocking down expression of this gene results in decreased Androgen Receptor protein levels, indicating that this gene may be important in modulating Androgen Receptor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

NWD1 Products (3)

mRNA Protein Name
NM_001007525.5 NP_001007526.3 NACHT domain- and WD repeat-containing protein 1 isoform 1
NM_001290355.3 NP_001277284.1 NACHT domain- and WD repeat-containing protein 1 isoform 2
NM_001347994.1 NP_001334923.1 NACHT domain- and WD repeat-containing protein 1 isoform 3

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
24681825 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24681825 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
24681825 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NWD1 Protein Structure

NACHT

NACHT: NACHT domain (337 - 505)

WD40

WD40: WD domain, G-beta repeat (903 - 938)

WD40

WD40: WD domain, G-beta repeat (1384 - 1416)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1564 a.a.
Protein Preferred Names Protein Names

NACHT domain- and WD repeat-containing protein 1

  • NACHT and WD repeat domain-containing protein 1

Related Diseases

Diseases Alias
Niemann-Pick Disease, Type C2

  • NPC2

  • Niemann-Pick Disease Type C2

  • Niemann-Pick C2 Disease

  • Niemann-Pick Disease C2
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09708 NWD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NWD1 VGNC VGNC:84898
Mus musculus NWD1 MGD MGI:2442268
Canis familiaris NWD1 VGNC VGNC:44069
Bos taurus NWD1 VGNC VGNC:32373
Felis catus NWD1 VGNC VGNC:63933
Rattus norvegicus NWD1 RGD RGD:2321209
Others NWD1 NCBI