TAFA3 - TAFA chemokine like family member 3 Gene

Also Known as TAFA-3; FAM19A3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 284467

About TAFA3

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:112,718,905-112,727,235 (from NCBI)

This gene has 2 transcripts (splice variants), 383 orthologues and 3 paralogues. Biased expression in adrenal (RPKM 7.0) and testis (RPKM 3.0).

Summary

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

TAFA3 Products (2)

mRNA Protein Name
NM_001004440.2 NP_001004440.1 chemokine-like protein TAFA-3 isoform 2 precursor
NM_182759.3 NP_877436.1 chemokine-like protein TAFA-3 isoform 1 precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
25595455 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAFA3 Protein Structure

TAFA

TAFA: TAFA family (42 - 131)

  • 0
  • 100
  • 133 a.a.
Protein Preferred Names Protein Names

chemokine-like protein TAFA-3

  • family with sequence similarity 19 (chemokine (C-C motif)-like), member A3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14181 TAFA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TAFA3 MGD MGI:3046463
Bos taurus TAFA3 VGNC VGNC:106963
Macaca mulatta TAFA3 VGNC VGNC:78190
Rattus norvegicus TAFA3 RGD RGD:1587462
Felis catus TAFA3 VGNC VGNC:82544
Others TAFA3 NCBI