Map2k4 - mitogen activated protein kinase kinase 4 Gene

Also Known as MKK4; Sek1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 287398

Summary

Enables ATP binding activity; JUN kinase kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including cellular response to sorbitol; positive regulation of JNK cascade; and positive regulation of macromolecule metabolic process. Located in several cellular components, including axon; dendrite cytoplasm; and perikaryon. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system Cancer (multiple); and urinary bladder Cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Map2k4 Products (1)

mRNA	Protein	Name
NM_001030023.2	NP_001025194.1	dual specificity mitogen-activated protein kinase kinase 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables JUN kinase kinase activity	IDA IDA: Inferred from direct assay	7768885	RGD
enables MAP kinase kinase activity	IDA IDA: Inferred from direct assay	7768885	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16805806	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in JNK cascade	IDA IDA: Inferred from direct assay	17064355	RGD
involved in cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	9769323	RGD
involved in cellular response to sorbitol	IEP IEP: Inferred from expression pattern	20550965	RGD
involved in positive regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	9487126	RGD
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	17064355	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12029621	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12514131	RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process	IMP IMP: Inferred from mutant phenotype	10593906	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	7768885	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	7768885	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	9714150	RGD
located in dendrite cytoplasm	IDA IDA: Inferred from direct assay	9714150	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	9714150	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dual specificity mitogen-activated protein kinase kinase 4	MAP2K4delta SAPK/ERK kinase 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-159190	HRX-0233	Inhibitor	98.92%	Unkown
HY-RS16235	Map2k4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08040	MAP2K4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map2k4	NCBI	NCBI:6416