Ppox - protoporphyrinogen oxidase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 289219

Summary

Enables oxygen-dependent protoporphyrinogen oxidase activity. Involved in heme biosynthetic process; protoporphyrinogen IX metabolic process; and response to xenobiotic stimulus. Located in mitochondrion. Is integral component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase). [provided by Alliance of Genome Resources, Apr 2022]

Ppox Products (1)

mRNA Protein Name
NM_001105968.1 NP_001099438.1 protoporphyrinogen oxidase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables oxygen-dependent protoporphyrinogen oxidase activity IDA
IDA: Inferred from direct assay
3663105 RGD
Biological Process GO Annotation Evidence References Source
involved in heme biosynthetic process IDA
IDA: Inferred from direct assay
3955059 RGD
involved in porphyrin-containing compound biosynthetic process IDA
IDA: Inferred from direct assay
3663105 RGD
involved in protoporphyrinogen IX metabolic process IDA
IDA: Inferred from direct assay
3663105 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
6316951 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
3996415 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protoporphyrinogen oxidase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10972 PPOX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-12464 Butafenacil 98.99% Unkown
HY-RS06050 HCRT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18943 Hcrt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppox NCBI NCBI:5498