GRIK4 - glutamate ionotropic receptor kainate type subunit 4 Gene

Also Known as KA1; EAA1; GRIK; GluK4; GluK4-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2900

About GRIK4

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:120,511,748-120,988,906 (from NCBI)

This gene has 8 transcripts (splice variants), 262 orthologues and 17 paralogues. Biased expression in brain (RPKM 2.8), ovary (RPKM 0.9) and 4 other tissues.

Summary

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GRIK4 Products (3)

mRNA Protein Name
NM_001282470.3 NP_001269399.1 glutamate receptor ionotropic, kainate 4 isoform 1 precursor
NM_001282473.3 NP_001269402.1 glutamate receptor ionotropic, kainate 4 isoform 2 precursor
NM_014619.5 NP_055434.2 glutamate receptor ionotropic, kainate 4 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
20026616 GOA
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
20026616 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRIK4 Protein Structure

ANF_receptor

ANF_receptor: Receptor family ligand binding region (45 - 380)

Lig_chan-Glu_bd

Lig_chan-Glu_bd: Ligated ion channel L-glutamate- and glycine-binding site (427 - 490)

Lig_chan

Lig_chan: Ligand-gated ion channel (547 - 816)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 956 a.a.
Protein Preferred Names Protein Names

glutamate receptor ionotropic, kainate 4

  • GluK4(alt_5'UTR)

GRIK4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82134 KA1 Antibody (YA1879) WB Human, Mouse, Rat
HY-P84608 KA1 Antibody (YA4305) IHC-P, ICC/IF, FC, ELISA Human
HY-P84608A KA1 Antibody (YA4305)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b

  • Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b, Remitting, With Or Without Mental Retardation
Depersonalization Disorder

  • Neurotic Derealization

  • Depersonalization

  • Depersonalization/Derealization Disorder

  • Depersonalisation-Derealization Syndrome

  • Depersonalisation Disorder

  • Depersonalisation Neurosis

  • Depersonalisation Syndrome

  • Feeling Of Unreality

  • Feels Own Self Is Unreal

  • Neurotic State With Depersonalisation

  • Neurotic State With Depersonalization Episode
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Megalencephalic Leukoencephalopathy With Subcortical Cysts 2a

  • MLC2A

  • Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 2a

  • Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 2a
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05801 GRIK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GRIK4 MGD MGI:95817
Felis catus GRIK4 VGNC VGNC:103032
Macaca mulatta GRIK4 VGNC VGNC:73279
Rattus norvegicus GRIK4 RGD RGD:2734
Canis familiaris GRIK4 VGNC VGNC:41489
Bos taurus GRIK4 VGNC VGNC:54882
Others GRIK4 NCBI